Serological Measures of Trachoma Transmission Intensity

Ocular infection with Chlamydia trachomatis can lead to trachoma, a leading infectious cause of blindness. Trachoma is targeted for elimination by 2020. Clinical grading for ocular disease is currently used for evaluating trachoma elimination programs, but serological surveillance can be a sensitive...

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Autores principales: Martin, Diana L., Wiegand, Ryan, Goodhew, Brook, Lammie, Patrick, Black, Carolyn M., West, Sheila, Gaydos, Charlotte A., Dize, Laura, Mkocha, Harran, Kasubi, Mabula, Gambhir, Manoj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685243/
https://www.ncbi.nlm.nih.gov/pubmed/26687891
http://dx.doi.org/10.1038/srep18532
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author Martin, Diana L.
Wiegand, Ryan
Goodhew, Brook
Lammie, Patrick
Black, Carolyn M.
West, Sheila
Gaydos, Charlotte A.
Dize, Laura
Mkocha, Harran
Kasubi, Mabula
Gambhir, Manoj
author_facet Martin, Diana L.
Wiegand, Ryan
Goodhew, Brook
Lammie, Patrick
Black, Carolyn M.
West, Sheila
Gaydos, Charlotte A.
Dize, Laura
Mkocha, Harran
Kasubi, Mabula
Gambhir, Manoj
author_sort Martin, Diana L.
collection PubMed
description Ocular infection with Chlamydia trachomatis can lead to trachoma, a leading infectious cause of blindness. Trachoma is targeted for elimination by 2020. Clinical grading for ocular disease is currently used for evaluating trachoma elimination programs, but serological surveillance can be a sensitive measure of disease transmission and provide a more objective testing strategy than clinical grading. We calculated the basic reproduction number from serological data in settings with high, medium, and low disease transmission based on clinical disease. The data showed a striking relationship between age seroprevalence and clinical data, demonstrating the proof-of-principle that age seroprevalence predicts transmission rates and therefore could be used as an indicator of decreased transmission of ocular trachoma.
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spelling pubmed-46852432015-12-30 Serological Measures of Trachoma Transmission Intensity Martin, Diana L. Wiegand, Ryan Goodhew, Brook Lammie, Patrick Black, Carolyn M. West, Sheila Gaydos, Charlotte A. Dize, Laura Mkocha, Harran Kasubi, Mabula Gambhir, Manoj Sci Rep Article Ocular infection with Chlamydia trachomatis can lead to trachoma, a leading infectious cause of blindness. Trachoma is targeted for elimination by 2020. Clinical grading for ocular disease is currently used for evaluating trachoma elimination programs, but serological surveillance can be a sensitive measure of disease transmission and provide a more objective testing strategy than clinical grading. We calculated the basic reproduction number from serological data in settings with high, medium, and low disease transmission based on clinical disease. The data showed a striking relationship between age seroprevalence and clinical data, demonstrating the proof-of-principle that age seroprevalence predicts transmission rates and therefore could be used as an indicator of decreased transmission of ocular trachoma. Nature Publishing Group 2015-12-21 /pmc/articles/PMC4685243/ /pubmed/26687891 http://dx.doi.org/10.1038/srep18532 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Martin, Diana L.
Wiegand, Ryan
Goodhew, Brook
Lammie, Patrick
Black, Carolyn M.
West, Sheila
Gaydos, Charlotte A.
Dize, Laura
Mkocha, Harran
Kasubi, Mabula
Gambhir, Manoj
Serological Measures of Trachoma Transmission Intensity
title Serological Measures of Trachoma Transmission Intensity
title_full Serological Measures of Trachoma Transmission Intensity
title_fullStr Serological Measures of Trachoma Transmission Intensity
title_full_unstemmed Serological Measures of Trachoma Transmission Intensity
title_short Serological Measures of Trachoma Transmission Intensity
title_sort serological measures of trachoma transmission intensity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685243/
https://www.ncbi.nlm.nih.gov/pubmed/26687891
http://dx.doi.org/10.1038/srep18532
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