An ancestral host defence peptide within human β-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule

Host defence peptides (HDPs) are critical components of innate immunity. Despite their diversity, they share common features including a structural signature, designated “γ-core motif”. We reasoned that for each HDPs evolved from an ancestral γ-core, the latter should be the evolutionary starting po...

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Detalles Bibliográficos
Autores principales: Nigro, Ersilia, Colavita, Irene, Sarnataro, Daniela, Scudiero, Olga, Zambrano, Gerardo, Granata, Vincenzo, Daniele, Aurora, Carotenuto, Alfonso, Galdiero, Stefania, Folliero, Veronica, Galdiero, Massimiliano, Urbanowicz, Richard A., Ball, Jonathan K., Salvatore, Francesco, Pessi, Antonello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685272/
https://www.ncbi.nlm.nih.gov/pubmed/26688341
http://dx.doi.org/10.1038/srep18450

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