Nitroxyl (HNO): A Reduced Form of Nitric Oxide with Distinct Chemical, Pharmacological, and Therapeutic Properties

Nitroxyl (HNO), the one-electron reduced form of nitric oxide (NO), shows a distinct chemical and biological profile from that of NO. HNO is currently being viewed as a vasodilator and positive inotropic agent that can be used as a potential treatment for heart failure. The ability of HNO to react w...

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Detalles Bibliográficos
Autores principales: Shoman, Mai E., Aly, Omar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685437/
https://www.ncbi.nlm.nih.gov/pubmed/26770654
http://dx.doi.org/10.1155/2016/4867124
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author Shoman, Mai E.
Aly, Omar M.
author_facet Shoman, Mai E.
Aly, Omar M.
author_sort Shoman, Mai E.
collection PubMed
description Nitroxyl (HNO), the one-electron reduced form of nitric oxide (NO), shows a distinct chemical and biological profile from that of NO. HNO is currently being viewed as a vasodilator and positive inotropic agent that can be used as a potential treatment for heart failure. The ability of HNO to react with thiols and thiol containing proteins is largely used to explain the possible biological actions of HNO. Herein, we summarize different aspects related to HNO including HNO donors, chemistry, biology, and methods used for its detection.
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spelling pubmed-46854372016-01-14 Nitroxyl (HNO): A Reduced Form of Nitric Oxide with Distinct Chemical, Pharmacological, and Therapeutic Properties Shoman, Mai E. Aly, Omar M. Oxid Med Cell Longev Review Article Nitroxyl (HNO), the one-electron reduced form of nitric oxide (NO), shows a distinct chemical and biological profile from that of NO. HNO is currently being viewed as a vasodilator and positive inotropic agent that can be used as a potential treatment for heart failure. The ability of HNO to react with thiols and thiol containing proteins is largely used to explain the possible biological actions of HNO. Herein, we summarize different aspects related to HNO including HNO donors, chemistry, biology, and methods used for its detection. Hindawi Publishing Corporation 2016 2015-12-07 /pmc/articles/PMC4685437/ /pubmed/26770654 http://dx.doi.org/10.1155/2016/4867124 Text en Copyright © 2016 M. E. Shoman and O. M. Aly. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shoman, Mai E.
Aly, Omar M.
Nitroxyl (HNO): A Reduced Form of Nitric Oxide with Distinct Chemical, Pharmacological, and Therapeutic Properties
title Nitroxyl (HNO): A Reduced Form of Nitric Oxide with Distinct Chemical, Pharmacological, and Therapeutic Properties
title_full Nitroxyl (HNO): A Reduced Form of Nitric Oxide with Distinct Chemical, Pharmacological, and Therapeutic Properties
title_fullStr Nitroxyl (HNO): A Reduced Form of Nitric Oxide with Distinct Chemical, Pharmacological, and Therapeutic Properties
title_full_unstemmed Nitroxyl (HNO): A Reduced Form of Nitric Oxide with Distinct Chemical, Pharmacological, and Therapeutic Properties
title_short Nitroxyl (HNO): A Reduced Form of Nitric Oxide with Distinct Chemical, Pharmacological, and Therapeutic Properties
title_sort nitroxyl (hno): a reduced form of nitric oxide with distinct chemical, pharmacological, and therapeutic properties
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685437/
https://www.ncbi.nlm.nih.gov/pubmed/26770654
http://dx.doi.org/10.1155/2016/4867124
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