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The immunological effect of hyaluronan in tumor angiogenesis

The relationship between the immune system and angiogenesis has been described in several contexts, both in physiological and pathological conditions, as pregnancy and cancer. In fact, different types of immune cells, such as myeloid, macrophages and denditric cells, are able to modulate tumor neova...

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Autores principales: Spinelli, Fiorella M, Vitale, Daiana L, Demarchi, Gianina, Cristina, Carolina, Alaniz, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685440/
https://www.ncbi.nlm.nih.gov/pubmed/26719798
http://dx.doi.org/10.1038/cti.2015.35
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author Spinelli, Fiorella M
Vitale, Daiana L
Demarchi, Gianina
Cristina, Carolina
Alaniz, Laura
author_facet Spinelli, Fiorella M
Vitale, Daiana L
Demarchi, Gianina
Cristina, Carolina
Alaniz, Laura
author_sort Spinelli, Fiorella M
collection PubMed
description The relationship between the immune system and angiogenesis has been described in several contexts, both in physiological and pathological conditions, as pregnancy and cancer. In fact, different types of immune cells, such as myeloid, macrophages and denditric cells, are able to modulate tumor neovascularization. On the other hand, tumor microenvironment also includes extracellular matrix components like hyaluronan, which has a deregulated synthesis in different tumors. Hyaluronan is a glycosaminoglycan, normally present in the extracellular matrix of tissues in continuous remodeling (embryogenesis or wound healing processes) and acts as an important modulator of cell behavior by different mechanisms, including angiogenesis. In this review, we discuss hyaluronan as a modulator of tumor angiogenesis, focusing in intracellular signaling mediated by its receptors expressed on different immune cells. Recent observations suggest that the immune system is an important component in tumoural angiogenesis. Therefore, immune modulation could have an impact in anti-angiogenic therapy as a new therapeutic strategy, which in turn might improve effectiveness of treatment in cancer patients.
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spelling pubmed-46854402015-12-30 The immunological effect of hyaluronan in tumor angiogenesis Spinelli, Fiorella M Vitale, Daiana L Demarchi, Gianina Cristina, Carolina Alaniz, Laura Clin Transl Immunology Review The relationship between the immune system and angiogenesis has been described in several contexts, both in physiological and pathological conditions, as pregnancy and cancer. In fact, different types of immune cells, such as myeloid, macrophages and denditric cells, are able to modulate tumor neovascularization. On the other hand, tumor microenvironment also includes extracellular matrix components like hyaluronan, which has a deregulated synthesis in different tumors. Hyaluronan is a glycosaminoglycan, normally present in the extracellular matrix of tissues in continuous remodeling (embryogenesis or wound healing processes) and acts as an important modulator of cell behavior by different mechanisms, including angiogenesis. In this review, we discuss hyaluronan as a modulator of tumor angiogenesis, focusing in intracellular signaling mediated by its receptors expressed on different immune cells. Recent observations suggest that the immune system is an important component in tumoural angiogenesis. Therefore, immune modulation could have an impact in anti-angiogenic therapy as a new therapeutic strategy, which in turn might improve effectiveness of treatment in cancer patients. Nature Publishing Group 2015-12-04 /pmc/articles/PMC4685440/ /pubmed/26719798 http://dx.doi.org/10.1038/cti.2015.35 Text en Copyright © 2015 Australasian Society for Immunology Inc. http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Review
Spinelli, Fiorella M
Vitale, Daiana L
Demarchi, Gianina
Cristina, Carolina
Alaniz, Laura
The immunological effect of hyaluronan in tumor angiogenesis
title The immunological effect of hyaluronan in tumor angiogenesis
title_full The immunological effect of hyaluronan in tumor angiogenesis
title_fullStr The immunological effect of hyaluronan in tumor angiogenesis
title_full_unstemmed The immunological effect of hyaluronan in tumor angiogenesis
title_short The immunological effect of hyaluronan in tumor angiogenesis
title_sort immunological effect of hyaluronan in tumor angiogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685440/
https://www.ncbi.nlm.nih.gov/pubmed/26719798
http://dx.doi.org/10.1038/cti.2015.35
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