Cargando…

A semi-automated luminescence based standard membrane feeding assay identifies novel small molecules that inhibit transmission of malaria parasites by mosquitoes

Current first-line treatments for uncomplicated falciparum malaria rapidly clear the asexual stages of the parasite, but do not fully prevent parasite transmission by mosquitoes. The standard membrane feeding assay (SMFA) is the biological gold standard assessment of transmission reducing activity (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vos, Martijn W., Stone, Will J. R., Koolen, Karin M., van Gemert, Geert-Jan, van Schaijk, Ben, Leroy, Didier, Sauerwein, Robert W., Bousema, Teun, Dechering, Koen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685452/ https://www.ncbi.nlm.nih.gov/pubmed/26687564 http://dx.doi.org/10.1038/srep18704

Ejemplares similares

Modelling mosquito infection at natural parasite densities identifies drugs targeting EF2, PI4K or ATP4 as key candidates for interrupting malaria transmission
por: Dechering, Koen J., et al.
Publicado: (2017)

Variation in susceptibility of African Plasmodium falciparum malaria parasites to TEP1 mediated killing in Anopheles gambiae mosquitoes
por: Eldering, Maarten, et al.
Publicado: (2016)

Concentration of Plasmodium falciparum gametocytes in whole blood samples by magnetic cell sorting enhances parasite infection rates in mosquito feeding assays
por: Reuling, Isaie J., et al.
Publicado: (2017)

An inter-laboratory comparison of standard membrane-feeding assays for evaluation of malaria transmission-blocking vaccines
por: Miura, Kazutoyo, et al.
Publicado: (2016)

A portfolio of geographically distinct laboratory-adapted Plasmodium falciparum clones with consistent infection rates in Anopheles mosquitoes
por: van de Vegte-Bolmer, Marga, et al.
Publicado: (2021)

Semi-high-throughput detection of Plasmodium falciparum and Plasmodium vivax oocysts in mosquitoes using bead-beating followed by circumsporozoite ELISA and quantitative PCR
por: Graumans, Wouter, et al.
Publicado: (2017)

A mosquito feeding assay to examine Plasmodium transmission to mosquitoes using small blood volumes in 3D printed nano-feeders
por: Graumans, Wouter, et al.
Publicado: (2020)

The relevance and applicability of oocyst prevalence as a read-out for mosquito feeding assays
por: Stone, Will J. R., et al.
Publicado: (2013)

Human antibodies against noncircumsporozoite proteins block Plasmodium falciparum parasite development in hepatocytes
por: Fabra-García, Amanda, et al.
Publicado: (2022)

Barcoded Asaia bacteria enable mosquito in vivo screens and identify novel systemic insecticides and inhibitors of malaria transmission
por: Sturm, Angelika, et al.
Publicado: (2021)

Monoclonal antibodies block transmission of genetically diverse Plasmodium falciparum strains to mosquitoes
por: de Jong, Roos M., et al.
Publicado: (2021)

Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes
por: Fabra-García, Amanda, et al.
Publicado: (2023)

Hijacking the human complement inhibitor C4b-binding protein by the sporozoite stage of the Plasmodium falciparum parasite
por: Khattab, Ayman, et al.
Publicado: (2022)

Removal of Heterologous Sequences from Plasmodium falciparum Mutants Using FLPe-Recombinase
por: van Schaijk, Ben C. L., et al.
Publicado: (2010)

Comparative assessment of An. gambiae and An. stephensi mosquitoes to determine transmission-reducing activity of antibodies against P. falciparum sexual stage antigens
por: Eldering, Maarten, et al.
Publicado: (2017)

Malaria Infected Mosquitoes Express Enhanced Attraction to Human Odor
por: Smallegange, Renate C., et al.
Publicado: (2013)

Assessment of the drugability of initial malaria infection through miniaturized sporozoite assays and high-throughput screening
por: Miglianico, Marie, et al.
Publicado: (2023)

A Randomized Clinical Trial to Compare Plasmodium falciparum Gametocytemia and Infectivity After Blood-Stage or Mosquito Bite–Induced Controlled Malaria Infection
por: Alkema, Manon, et al.
Publicado: (2020)

Corrigendum to: A Randomized Clinical Trial to Compare Plasmodium falciparum Gametocytemia and Infectivity After Blood-Stage or Mosquito Bite–Induced Controlled Malaria Infection
por: Alkema, Manon, et al.
Publicado: (2020)

Extended malaria parasite clearance time in African children following artemisinin-combination therapy enhances transmission to Anopheles mosquitoes
por: Beshir, Khalid B, et al.
Publicado: (2012)

Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression
por: Lasonder, Edwin, et al.
Publicado: (2016)

Comparative analysis of glass and Hemotek membrane feeding systems for malaria transmission research
por: Graumans, Wouter, et al.
Publicado: (2023)

Residual Plasmodium falciparum Parasitemia in Kenyan Children After Artemisinin-Combination Therapy Is Associated With Increased Transmission to Mosquitoes and Parasite Recurrence
por: Beshir, Khalid B., et al.
Publicado: (2013)

Evaluation of immunity against malaria using luciferase-expressing Plasmodium berghei parasites
por: Ploemen, Ivo, et al.
Publicado: (2011)

Zonal human hepatocytes are differentially permissive to Plasmodium falciparum malaria parasites
por: Yang, Annie S P, et al.
Publicado: (2021)

Estimating female malaria mosquito age by quantifying Y-linked genes in stored male spermatozoa
por: Madan, Damian, et al.
Publicado: (2022)

Overuse of artemisinin-combination therapy in Mto wa Mbu (river of mosquitoes), an area misinterpreted as high endemic for malaria
por: Mwanziva, Charles, et al.
Publicado: (2008)

The Dynamics of Naturally Acquired Immune Responses to Plasmodium falciparum Sexual Stage Antigens Pfs230 & Pfs48/45 in a Low Endemic Area in Tanzania
por: Bousema, Teun, et al.
Publicado: (2010)

Mid-Liver Stage Arrest of Plasmodium falciparum Schizonts in Primary Porcine Hepatocytes
por: van der Boor, Saskia C., et al.
Publicado: (2022)

Assessing Plasmodium falciparum transmission in mosquito-feeding assays using quantitative PCR
por: Wang, Claire Y. T., et al.
Publicado: (2018)

Quantifying Reductions in Plasmodium falciparum Infectivity to Mosquitos: A Sample Size Calculator to Inform Clinical Trials on Transmission-Reducing Interventions
por: Ramjith, Jordache, et al.
Publicado: (2022)

Plasmodium berghei Δp52&p36 Parasites Develop Independent of a Parasitophorous Vacuole Membrane in Huh-7 Liver Cells
por: Ploemen, Ivo H. J., et al.
Publicado: (2012)

Odours of Plasmodium falciparum-infected participants influence mosquito-host interactions
por: de Boer, Jetske G., et al.
Publicado: (2017)

The effect of anticoagulants in blood collection tubes on Plasmodium falciparum transmission in direct membrane feeding assays
por: Graumans, Wouter, et al.
Publicado: (2021)

Is that a real oocyst? Insectary establishment and identification of Plasmodium falciparum oocysts in midguts of Anopheles mosquitoes fed on infected human blood in Tororo, Uganda
por: Musiime, Alex K., et al.
Publicado: (2019)

Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites
por: Meerstein-Kessel, Lisette, et al.
Publicado: (2018)

Controlled human malaria infections by mosquito bites induce more severe clinical symptoms than asexual blood-stage challenge infections
por: Alkema, Manon, et al.
Publicado: (2022)

Functional antibodies against Plasmodium falciparum sporozoites are associated with a longer time to qPCR-detected infection among schoolchildren in Burkina Faso
por: Barry, Aissata, et al.
Publicado: (2019)

A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites
por: van Schaijk, Ben C L, et al.
Publicado: (2014)

Three Members of the 6-cys Protein Family of Plasmodium Play a Role in Gamete Fertility
por: van Dijk, Melissa R., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_m78lamk5b0t5vfvbrndmlv9mv0