Cargando…

Comparative transcriptome analysis of different chemotypes elucidates withanolide biosynthesis pathway from medicinal plant Withania somnifera

Withania somnifera is one of the most valuable medicinal plants synthesizing secondary metabolites known as withanolides. Despite pharmaceutical importance, limited information is available about the biosynthesis of withanolides. Chemo-profiling of leaf and root tissues of Withania suggest differenc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gupta, Parul, Goel, Ridhi, Agarwal, Aditya Vikram, Asif, Mehar Hasan, Sangwan, Neelam Singh, Sangwan, Rajender Singh, Trivedi, Prabodh Kumar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685652/ https://www.ncbi.nlm.nih.gov/pubmed/26688389 http://dx.doi.org/10.1038/srep18611

Ejemplares similares

De Novo Assembly, Functional Annotation and Comparative Analysis of Withania somnifera Leaf and Root Transcriptomes to Identify Putative Genes Involved in the Withanolides Biosynthesis
por: Gupta, Parul, et al.
Publicado: (2013)

Comparative interactions of withanolides and sterols with two members of sterol glycosyltransferases from Withania somnifera
por: Pandey, Vibha, et al.
Publicado: (2015)

RNAi and Homologous Over-Expression Based Functional Approaches Reveal Triterpenoid Synthase Gene-Cycloartenol Synthase Is Involved in Downstream Withanolide Biosynthesis in Withania somnifera
por: Mishra, Smrati, et al.
Publicado: (2016)

Transcription factor repertoire in Ashwagandha (Withania somnifera) through analytics of transcriptomic resources: Insights into regulation of development and withanolide metabolism
por: Tripathi, Sandhya, et al.
Publicado: (2017)

Silencing of sterol glycosyltransferases modulates the withanolide biosynthesis and leads to compromised basal immunity of Withania somnifera
por: Singh, Gaurav, et al.
Publicado: (2016)

In silico mining and functional analysis of AP2/ERF gene in Withania somnifera
por: Tripathi, Sandhya, et al.
Publicado: (2020)

Tropine Forming Tropinone Reductase Gene from Withania somnifera (Ashwagandha): Biochemical Characteristics of the Recombinant Enzyme and Novel Physiological Overtones of Tissue-Wide Gene Expression Patterns
por: Kushwaha, Amit Kumar, et al.
Publicado: (2013)

Endophytes of Withania somnifera modulate in planta content and the site of withanolide biosynthesis
por: Pandey, Shiv S., et al.
Publicado: (2018)

Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera)
por: Lee, Seoung Rak, et al.
Publicado: (2022)

Differential Gene Expression and Withanolides Biosynthesis During in vitro and ex vitro Growth of Withania somnifera (L.) Dunal
por: Thorat, Sachin Ashok, et al.
Publicado: (2022)

Optimization of Elicitation Conditions to Enhance the Production of Potent Metabolite Withanolide from Withania somnifera (L.)
por: Singh, Manali, et al.
Publicado: (2022)

Evaluation of the bioavailability of major withanolides of Withania somnifera using an in vitro absorption model system
por: Devkar, Santosh T., et al.
Publicado: (2015)

Structural Characterization of Withanolide Glycosides from the Roots of Withania somnifera and Their Potential Biological Activities
por: Ha, Ji Won, et al.
Publicado: (2022)

Investigating 11 Withanosides and Withanolides by UHPLC–PDA and Mass Fragmentation Studies from Ashwagandha (Withania somnifera)
por: Girme, Aboli, et al.
Publicado: (2020)

Withasomniferol D, a New Anti-Adipogenic Withanolide from the Roots of Ashwagandha (Withania somnifera)
por: Lee, Bum Soo, et al.
Publicado: (2021)

A Decade of Molecular Understanding of Withanolide Biosynthesis and In vitro Studies in Withania somnifera (L.) Dunal: Prospects and Perspectives for Pathway Engineering
por: Dhar, Niha, et al.
Publicado: (2015)

Transcriptome analysis reveals in vitro cultured Withania somnifera leaf and root tissues as a promising source for targeted withanolide biosynthesis
por: Senthil, Kalaiselvi, et al.
Publicado: (2015)

Enhanced Biosynthesis of Withanolides by Elicitation and Precursor Feeding in Cell Suspension Culture of Withania somnifera (L.) Dunal in Shake-Flask Culture and Bioreactor
por: Sivanandhan, Ganeshan, et al.
Publicado: (2014)

Estimating the production of withaferin A and withanolide A in Withania somnifera (L.) dunal using aquaponics for sustainable development in hill agriculture
por: Singh, Manali, et al.
Publicado: (2023)

Withania Coagulans and Somnifera
por: Verghese, M.
Publicado: (1885)

Withania somnifera Improves Semen Quality in Stress-Related Male Fertility
por: Mahdi, Abbas Ali, et al.
Publicado: (2011)

Triethylene glycol-like effects of Ashwagandha (Withania somnifera (L.) Dunal) root extract devoid of withanolides in stressed mice
por: Dey, Amitabha, et al.
Publicado: (2018)

Molecular characterization of three CYP450 genes reveals their role in withanolides formation and defense in Withania somnifera, the Indian Ginseng
por: Shilpashree, H. B., et al.
Publicado: (2022)

Pharmacokinetic Study of Withanosides and Withanolides from Withania somnifera Using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-MS/MS)
por: Modi, Siddharth J., et al.
Publicado: (2022)

Stability indicating studies on NMITLI 118RT+ (standardized extract of withania somnifera dunal)
por: Ahmad, Hafsa, et al.
Publicado: (2014)

Evaluation of Antimicrobial Efficacy of Flavonoids of Withania Somnifera L.
por: Singh, G., et al.
Publicado: (2011)

Rapid metabolic fingerprinting with the aid of chemometric models to identify authenticity of natural medicines: Turmeric, Ocimum, and Withania somnifera study
por: Khan, Samreen, et al.
Publicado: (2023)

Molecular Cloning and Biochemical Characterization of a Recombinant Sterol 3-O-Glucosyltransferase from Gymnema sylvestre R.Br. Catalyzing Biosynthesis of Steryl Glucosides
por: Tiwari, Pragya, et al.
Publicado: (2014)

Ashwagandha (Withania somnifera) supercritical CO(2) extract derived withanolides mitigates Bisphenol A induced mitochondrial toxicity in HepG2 cells
por: Vidyashankar, Satyakumar, et al.
Publicado: (2014)

Roots of Withania somnifera Inhibit Forestomach and Skin Carcinogenesis in Mice
por: Padmavathi, Bandhuvula, et al.
Publicado: (2005)

Genome-wide Expression Analysis and Metabolite Profiling Elucidate Transcriptional Regulation of Flavonoid Biosynthesis and Modulation under Abiotic Stresses in Banana
por: Pandey, Ashutosh, et al.
Publicado: (2016)

In vitro screening of neuroprotective activity of Indian medicinal plant Withania somnifera
por: Singh, Manjeet, et al.
Publicado: (2017)

Antitumor Potential of Withanolide Glycosides from Ashwagandha (Withania somnifera) on Apoptosis of Human Hepatocellular Carcinoma Cells and Tube Formation in Human Umbilical Vein Endothelial Cells
por: Lee, Dahae, et al.
Publicado: (2022)

Bak Compensated for Bax in p53-null Cells to Release Cytochrome c for the Initiation of Mitochondrial Signaling during Withanolide D-Induced Apoptosis
por: Mondal, Susmita, et al.
Publicado: (2012)

Withania somnifera: Advances and Implementation of Molecular and Tissue Culture Techniques to Enhance Its Application
por: Pandey, Vibha, et al.
Publicado: (2017)

Withania somnifera Extracts Promote Resilience against Age-Related and Stress-Induced Behavioral Phenotypes in Drosophila melanogaster; a Possible Role of Other Compounds besides Withanolides
por: Holvoet, Helen, et al.
Publicado: (2022)

Efficacy of Withania somnifera supplementation on adult’s cognition and mood
por: Remenapp, A., et al.
Publicado: (2022)

A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer
por: Dubey, Seema, et al.
Publicado: (2021)

Neuroprotective effects of Withania somnifera in BPA induced-cognitive dysfunction and oxidative stress in mice
por: Birla, Hareram, et al.
Publicado: (2019)

Isolation of Antidiabetic Withanolides from Withania coagulans Dunal and Their In Vitro and In Silico Validation
por: Maher, Saima, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_881iojt6i5fdcdo7hdfha2rvu6