Cargando…

Controlled Human Malaria Infection (CHMI) differentially affects cell-mediated and antibody responses to CSP and AMA1 induced by adenovirus vaccines with and without DNA-priming

We have previously shown that a DNA-prime followed by an adenovirus-5 boost vaccine containing CSP and AMA1 (DNA/Ad) successfully protected 4 of 15 subjects to controlled human malaria infection (CHMI). However, the adenovirus-5 vaccine alone (AdCA) failed to induce protection despite eliciting cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sedegah, Martha, Hollingdale, Michael R, Farooq, Fouzia, Ganeshan, Harini, Belmonte, Maria, Huang, Jun, Abot, Esteban, Limbach, Keith, Chuang, Ilin, Tamminga, Cindy, Epstein, Judith E, Villasante, Eileen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2015
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685686/ https://www.ncbi.nlm.nih.gov/pubmed/26292027 http://dx.doi.org/10.1080/21645515.2015.1019186

Ejemplares similares

Sterile Immunity to Malaria after DNA Prime/Adenovirus Boost Immunization Is Associated with Effector Memory CD8+T Cells Targeting AMA1 Class I Epitopes
por: Sedegah, Martha, et al.
Publicado: (2014)

Adenovirus-5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part B: Safety, Immunogenicity and Protective Efficacy of the CSP Component
por: Tamminga, Cindy, et al.
Publicado: (2011)

Adenovirus 5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part A: Safety and Immunogenicity in Seronegative Adults
por: Sedegah, Martha, et al.
Publicado: (2011)

DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity
por: Chuang, Ilin, et al.
Publicado: (2013)

Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP)
por: Sedegah, Martha, et al.
Publicado: (2013)

Human adenovirus 5-vectored Plasmodium falciparum NMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against controlled human malaria infection
por: Tamminga, Cindy, et al.
Publicado: (2013)

IMRAS—Immunization with radiation-attenuated Plasmodium falciparum sporozoites by mosquito bite: Cellular immunity to sporozoites, CSP, AMA1, TRAP and CelTOS
por: Sedegah, Martha, et al.
Publicado: (2021)

Measurement of ex vivo ELISpot interferon-gamma recall responses to Plasmodium falciparum AMA1 and CSP in Ghanaian adults with natural exposure to malaria
por: Ganeshan, Harini, et al.
Publicado: (2016)

Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein
por: Sedegah, Martha, et al.
Publicado: (2010)

Vaccine Strain-Specificity of Protective HLA-Restricted Class 1 P. falciparum Epitopes
por: Sedegah, Martha, et al.
Publicado: (2016)

Correction: Vaccine Strain-Specificity of Protective HLA-Restricted Class 1 P. falciparum Epitopes
por: Sedegah, Martha, et al.
Publicado: (2016)

Comparison of the impact of allelic polymorphisms in PfAMA1 on the induction of T Cell responses in high and low malaria endemic communities in Ghana
por: Ofori, Ebenezer A., et al.
Publicado: (2021)

Comparative analysis of the ex vivo IFN-gamma responses to CD8+ T cell epitopes within allelic forms of PfAMA1 in subjects with natural exposure to malaria
por: Nlinwe, Omarine N., et al.
Publicado: (2021)

A three-antigen Plasmodium falciparum DNA prime—Adenovirus boost malaria vaccine regimen is superior to a two-antigen regimen and protects against controlled human malaria infection in healthy malaria-naïve adults
por: Sklar, Marvin J., et al.
Publicado: (2021)

Ex vivo tetramer staining and cell surface phenotyping for early activation markers CD38 and HLA-DR to enumerate and characterize malaria antigen-specific CD8(+) T-cells induced in human volunteers immunized with a Plasmodium falciparum adenovirus-vectored malaria vaccine expressing AMA1
por: Schwenk, Robert, et al.
Publicado: (2013)

New gorilla adenovirus vaccine vectors induce potent immune responses and protection in a mouse malaria model
por: Limbach, Keith, et al.
Publicado: (2017)

IMRAS—A clinical trial of mosquito-bite immunization with live, radiation-attenuated P. falciparum sporozoites: Impact of immunization parameters on protective efficacy and generation of a repository of immunologic reagents
por: Hickey, Bradley, et al.
Publicado: (2020)

CHARM: COVID-19 Health Action Response for Marines–Association of antigen-specific interferon-gamma and IL2 responses with asymptomatic and symptomatic infections after a positive qPCR SARS-CoV-2 test
por: Sedegah, Martha, et al.
Publicado: (2022)

Measuring naturally acquired ex vivo IFN-γ responses to Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites (CelTOS) in Ghanaian adults
por: Anum, Dorothy, et al.
Publicado: (2015)

Identification of Plasmodium falciparum circumsporozoite protein-specific CD8+ T cell epitopes in a malaria exposed population
por: Kusi, Kwadwo A., et al.
Publicado: (2020)

Perceptions and acceptability of the controlled human malaria infection (CHMI) model in The Gambia: a qualitative study
por: Dabira, Edgard Diniba, et al.
Publicado: (2023)

ReverCSP: Time-Travelling in CSP Computations
por: Galindo, Carlos, et al.
Publicado: (2020)

Identification of two new protective pre-erythrocytic malaria vaccine antigen candidates
por: Limbach, Keith, et al.
Publicado: (2011)

Prime-boost vaccination with recombinant protein and adenovirus-vector expressing Plasmodium vivax circumsporozoite protein (CSP) partially protects mice against Pb/Pv sporozoite challenge
por: de Camargo, Tarsila Mendes, et al.
Publicado: (2018)

Controlled human malaria infection (CHMI) outcomes in Kenyan adults is associated with prior history of malaria exposure and anti-schizont antibody response
por: Kapulu, Melissa C., et al.
Publicado: (2022)

Cellular interferon-gamma and interleukin-2 responses to SARS-CoV-2 structural proteins are broader and higher in those vaccinated after SARS-CoV-2 infection compared to vaccinees without prior SARS-CoV-2 infection
por: Sedegah, Martha, et al.
Publicado: (2022)

Virosome-Formulated Plasmodium falciparum AMA-1 & CSP Derived Peptides as Malaria Vaccine: Randomized Phase 1b Trial in Semi-Immune Adults & Children
por: Cech, Patrick Georges, et al.
Publicado: (2011)

Speakers AMA
por: CERN. Geneva
Publicado: (2019)

The AMA Handbook of Leadership
por: Goldsmith, Marshall, et al.
Publicado: (2010)

Induction of antigen specific intrahepatic CD8+ T cell responses by a secreted heat shock protein based gp96-Ig-PfCA malaria vaccine
por: Padula, Laura, et al.
Publicado: (2023)

Accelerated prime-and-trap vaccine regimen in mice using repRNA-based CSP malaria vaccine
por: MacMillen, Zachary, et al.
Publicado: (2023)

Accelerated prime-and-trap vaccine regimen in mice using repRNA-based CSP malaria vaccine
por: MacMillen, Zachary, et al.
Publicado: (2023)

Photoexcited Enzymes for Asymmetric Csp (3)−Csp (3) Cross‐Electrophile Couplings
por: Schmidt, Sandy
Publicado: (2022)

Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults
por: Dodoo, Daniel, et al.
Publicado: (2011)

El ama : memorias de una dominadora
por: Foucault, Annick
Publicado: (1996)

Evaluation of Chimpanzee Adenovirus and MVA Expressing TRAP and CSP from Plasmodium cynomolgi to Prevent Malaria Relapse in Nonhuman Primates
por: Kim, Young Chan, et al.
Publicado: (2020)

Novel malaria antigen Plasmodium yoelii E140 induces antibody-mediated sterile protection in mice against malaria challenge
por: Smith, Emily C., et al.
Publicado: (2020)

The AMA handbook of project management
Publicado: (1993)

The AMA handbook of business letters
por: Seglin, Jeffrey L, et al.
Publicado: (2012)

The AMA handbook of project management
por: Dinsmore, Paul C, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_rf6qdpqtund9pda1vj6qm5rgdl