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Au nanoparticle-based sensor for apomorphine detection in plasma

Artificially roughened gold surfaces with controlled nanostructure produced by pulsed laser deposition have been investigated as sensors for apomorphine detection aiming at clinical application. The use of such gold surfaces has been optimized using aqueous solutions of apomorphine in the concentrat...

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Autores principales: Zanchi, Chiara, Lucotti, Andrea, Tommasini, Matteo, Trusso, Sebastiano, de Grazia, Ugo, Ciusani, Emilio, Ossi, Paolo M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685758/
https://www.ncbi.nlm.nih.gov/pubmed/26734514
http://dx.doi.org/10.3762/bjnano.6.228
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author Zanchi, Chiara
Lucotti, Andrea
Tommasini, Matteo
Trusso, Sebastiano
de Grazia, Ugo
Ciusani, Emilio
Ossi, Paolo M
author_facet Zanchi, Chiara
Lucotti, Andrea
Tommasini, Matteo
Trusso, Sebastiano
de Grazia, Ugo
Ciusani, Emilio
Ossi, Paolo M
author_sort Zanchi, Chiara
collection PubMed
description Artificially roughened gold surfaces with controlled nanostructure produced by pulsed laser deposition have been investigated as sensors for apomorphine detection aiming at clinical application. The use of such gold surfaces has been optimized using aqueous solutions of apomorphine in the concentration range between 3.3 × 10(−4) M and 3.3 × 10(−7) M. The experimental parameters have been investigated and the dynamic concentration range of the sensor has been assessed by the selection of two apomorphine surface enhanced Raman scattering (SERS) peaks. The sensor behavior used to detect apomorphine in unfiltered human blood plasma is presented and discussed.
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spelling pubmed-46857582016-01-05 Au nanoparticle-based sensor for apomorphine detection in plasma Zanchi, Chiara Lucotti, Andrea Tommasini, Matteo Trusso, Sebastiano de Grazia, Ugo Ciusani, Emilio Ossi, Paolo M Beilstein J Nanotechnol Full Research Paper Artificially roughened gold surfaces with controlled nanostructure produced by pulsed laser deposition have been investigated as sensors for apomorphine detection aiming at clinical application. The use of such gold surfaces has been optimized using aqueous solutions of apomorphine in the concentration range between 3.3 × 10(−4) M and 3.3 × 10(−7) M. The experimental parameters have been investigated and the dynamic concentration range of the sensor has been assessed by the selection of two apomorphine surface enhanced Raman scattering (SERS) peaks. The sensor behavior used to detect apomorphine in unfiltered human blood plasma is presented and discussed. Beilstein-Institut 2015-11-26 /pmc/articles/PMC4685758/ /pubmed/26734514 http://dx.doi.org/10.3762/bjnano.6.228 Text en Copyright © 2015, Zanchi et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjnano/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Nanotechnology terms and conditions: (https://www.beilstein-journals.org/bjnano/terms)
spellingShingle Full Research Paper
Zanchi, Chiara
Lucotti, Andrea
Tommasini, Matteo
Trusso, Sebastiano
de Grazia, Ugo
Ciusani, Emilio
Ossi, Paolo M
Au nanoparticle-based sensor for apomorphine detection in plasma
title Au nanoparticle-based sensor for apomorphine detection in plasma
title_full Au nanoparticle-based sensor for apomorphine detection in plasma
title_fullStr Au nanoparticle-based sensor for apomorphine detection in plasma
title_full_unstemmed Au nanoparticle-based sensor for apomorphine detection in plasma
title_short Au nanoparticle-based sensor for apomorphine detection in plasma
title_sort au nanoparticle-based sensor for apomorphine detection in plasma
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685758/
https://www.ncbi.nlm.nih.gov/pubmed/26734514
http://dx.doi.org/10.3762/bjnano.6.228
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