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Au nanoparticle-based sensor for apomorphine detection in plasma
Artificially roughened gold surfaces with controlled nanostructure produced by pulsed laser deposition have been investigated as sensors for apomorphine detection aiming at clinical application. The use of such gold surfaces has been optimized using aqueous solutions of apomorphine in the concentrat...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Beilstein-Institut
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685758/ https://www.ncbi.nlm.nih.gov/pubmed/26734514 http://dx.doi.org/10.3762/bjnano.6.228 |
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author | Zanchi, Chiara Lucotti, Andrea Tommasini, Matteo Trusso, Sebastiano de Grazia, Ugo Ciusani, Emilio Ossi, Paolo M |
author_facet | Zanchi, Chiara Lucotti, Andrea Tommasini, Matteo Trusso, Sebastiano de Grazia, Ugo Ciusani, Emilio Ossi, Paolo M |
author_sort | Zanchi, Chiara |
collection | PubMed |
description | Artificially roughened gold surfaces with controlled nanostructure produced by pulsed laser deposition have been investigated as sensors for apomorphine detection aiming at clinical application. The use of such gold surfaces has been optimized using aqueous solutions of apomorphine in the concentration range between 3.3 × 10(−4) M and 3.3 × 10(−7) M. The experimental parameters have been investigated and the dynamic concentration range of the sensor has been assessed by the selection of two apomorphine surface enhanced Raman scattering (SERS) peaks. The sensor behavior used to detect apomorphine in unfiltered human blood plasma is presented and discussed. |
format | Online Article Text |
id | pubmed-4685758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-46857582016-01-05 Au nanoparticle-based sensor for apomorphine detection in plasma Zanchi, Chiara Lucotti, Andrea Tommasini, Matteo Trusso, Sebastiano de Grazia, Ugo Ciusani, Emilio Ossi, Paolo M Beilstein J Nanotechnol Full Research Paper Artificially roughened gold surfaces with controlled nanostructure produced by pulsed laser deposition have been investigated as sensors for apomorphine detection aiming at clinical application. The use of such gold surfaces has been optimized using aqueous solutions of apomorphine in the concentration range between 3.3 × 10(−4) M and 3.3 × 10(−7) M. The experimental parameters have been investigated and the dynamic concentration range of the sensor has been assessed by the selection of two apomorphine surface enhanced Raman scattering (SERS) peaks. The sensor behavior used to detect apomorphine in unfiltered human blood plasma is presented and discussed. Beilstein-Institut 2015-11-26 /pmc/articles/PMC4685758/ /pubmed/26734514 http://dx.doi.org/10.3762/bjnano.6.228 Text en Copyright © 2015, Zanchi et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjnano/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Nanotechnology terms and conditions: (https://www.beilstein-journals.org/bjnano/terms) |
spellingShingle | Full Research Paper Zanchi, Chiara Lucotti, Andrea Tommasini, Matteo Trusso, Sebastiano de Grazia, Ugo Ciusani, Emilio Ossi, Paolo M Au nanoparticle-based sensor for apomorphine detection in plasma |
title | Au nanoparticle-based sensor for apomorphine detection in plasma |
title_full | Au nanoparticle-based sensor for apomorphine detection in plasma |
title_fullStr | Au nanoparticle-based sensor for apomorphine detection in plasma |
title_full_unstemmed | Au nanoparticle-based sensor for apomorphine detection in plasma |
title_short | Au nanoparticle-based sensor for apomorphine detection in plasma |
title_sort | au nanoparticle-based sensor for apomorphine detection in plasma |
topic | Full Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685758/ https://www.ncbi.nlm.nih.gov/pubmed/26734514 http://dx.doi.org/10.3762/bjnano.6.228 |
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