A novel and practical asymmetric synthesis of dapoxetine hydrochloride

A novel and practical asymmetric synthesis of dapoxetine hydrochloride by using the chiral auxiliary (S)-tert-butanesulfinamide was explored. The synthesis was concise, mild, and easy to perform. The overall yield and stereoselectivity were excellent.

Detalles Bibliográficos
Autores principales: Zhu, Yijun, Liu, Zhenren, Li, Hongyan, Ye, Deyong, Zhou, Weicheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2015
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685759/
https://www.ncbi.nlm.nih.gov/pubmed/26734109
http://dx.doi.org/10.3762/bjoc.11.283
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author Zhu, Yijun
Liu, Zhenren
Li, Hongyan
Ye, Deyong
Zhou, Weicheng
author_facet Zhu, Yijun
Liu, Zhenren
Li, Hongyan
Ye, Deyong
Zhou, Weicheng
author_sort Zhu, Yijun
collection PubMed
description A novel and practical asymmetric synthesis of dapoxetine hydrochloride by using the chiral auxiliary (S)-tert-butanesulfinamide was explored. The synthesis was concise, mild, and easy to perform. The overall yield and stereoselectivity were excellent.
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spelling pubmed-46857592016-01-05 A novel and practical asymmetric synthesis of dapoxetine hydrochloride Zhu, Yijun Liu, Zhenren Li, Hongyan Ye, Deyong Zhou, Weicheng Beilstein J Org Chem Full Research Paper A novel and practical asymmetric synthesis of dapoxetine hydrochloride by using the chiral auxiliary (S)-tert-butanesulfinamide was explored. The synthesis was concise, mild, and easy to perform. The overall yield and stereoselectivity were excellent. Beilstein-Institut 2015-12-17 /pmc/articles/PMC4685759/ /pubmed/26734109 http://dx.doi.org/10.3762/bjoc.11.283 Text en Copyright © 2015, Zhu et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Zhu, Yijun
Liu, Zhenren
Li, Hongyan
Ye, Deyong
Zhou, Weicheng
A novel and practical asymmetric synthesis of dapoxetine hydrochloride
title A novel and practical asymmetric synthesis of dapoxetine hydrochloride
title_full A novel and practical asymmetric synthesis of dapoxetine hydrochloride
title_fullStr A novel and practical asymmetric synthesis of dapoxetine hydrochloride
title_full_unstemmed A novel and practical asymmetric synthesis of dapoxetine hydrochloride
title_short A novel and practical asymmetric synthesis of dapoxetine hydrochloride
title_sort novel and practical asymmetric synthesis of dapoxetine hydrochloride
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685759/
https://www.ncbi.nlm.nih.gov/pubmed/26734109
http://dx.doi.org/10.3762/bjoc.11.283
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