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Recent highlights in biosynthesis research using stable isotopes

The long and successful history of isotopic labeling experiments within natural products research has both changed and deepened our understanding of biosynthesis. As demonstrated in this article, the usage of isotopes is not at all old-fashioned, but continues to give important insights into biosynt...

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Detalles Bibliográficos
Autores principales: Rinkel, Jan, Dickschat, Jeroen S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685789/
https://www.ncbi.nlm.nih.gov/pubmed/26734097
http://dx.doi.org/10.3762/bjoc.11.271
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author Rinkel, Jan
Dickschat, Jeroen S
author_facet Rinkel, Jan
Dickschat, Jeroen S
author_sort Rinkel, Jan
collection PubMed
description The long and successful history of isotopic labeling experiments within natural products research has both changed and deepened our understanding of biosynthesis. As demonstrated in this article, the usage of isotopes is not at all old-fashioned, but continues to give important insights into biosynthetic pathways of secondary metabolites. This review with 85 cited references is structured by separate discussions of compounds from different classes including polyketides, non-ribosomal peptides, their hybrids, terpenoids, and aromatic compounds formed via the shikimate pathway. The text does not aim at a comprehensive overview, but instead a selection of recent important examples of isotope usage within biosynthetic studies is presented, with a special emphasis on mechanistic surprises.
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spelling pubmed-46857892016-01-05 Recent highlights in biosynthesis research using stable isotopes Rinkel, Jan Dickschat, Jeroen S Beilstein J Org Chem Review The long and successful history of isotopic labeling experiments within natural products research has both changed and deepened our understanding of biosynthesis. As demonstrated in this article, the usage of isotopes is not at all old-fashioned, but continues to give important insights into biosynthetic pathways of secondary metabolites. This review with 85 cited references is structured by separate discussions of compounds from different classes including polyketides, non-ribosomal peptides, their hybrids, terpenoids, and aromatic compounds formed via the shikimate pathway. The text does not aim at a comprehensive overview, but instead a selection of recent important examples of isotope usage within biosynthetic studies is presented, with a special emphasis on mechanistic surprises. Beilstein-Institut 2015-12-09 /pmc/articles/PMC4685789/ /pubmed/26734097 http://dx.doi.org/10.3762/bjoc.11.271 Text en Copyright © 2015, Rinkel and Dickschat https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Review
Rinkel, Jan
Dickschat, Jeroen S
Recent highlights in biosynthesis research using stable isotopes
title Recent highlights in biosynthesis research using stable isotopes
title_full Recent highlights in biosynthesis research using stable isotopes
title_fullStr Recent highlights in biosynthesis research using stable isotopes
title_full_unstemmed Recent highlights in biosynthesis research using stable isotopes
title_short Recent highlights in biosynthesis research using stable isotopes
title_sort recent highlights in biosynthesis research using stable isotopes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685789/
https://www.ncbi.nlm.nih.gov/pubmed/26734097
http://dx.doi.org/10.3762/bjoc.11.271
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