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The effect of low-sodium dialysate on ambulatory blood pressure measurement parameters in patients undergoing hemodialysis
BACKGROUND: End stage renal disease is related to increased cardiovascular mortality and morbidity. Hypertension is an important risk factor for cardiovascular disorder among hemodialysis (HD) patients. The aim of this study was to investigate the effect of low-sodium dialysate on the systolic blood...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685887/ https://www.ncbi.nlm.nih.gov/pubmed/26715849 http://dx.doi.org/10.2147/TCRM.S94889 |
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author | Akdag, Serkan Akyol, Aytac Cakmak, Huseyin Altug Tosu, Aydin Rodi Asker, Muntecep Yaman, Mehmet Babat, Naci Soyoral, Yasemin Cegin, Muhammed Bilal Gur, Ali Kemal Gumrukcuoglu, Hasan Ali |
author_facet | Akdag, Serkan Akyol, Aytac Cakmak, Huseyin Altug Tosu, Aydin Rodi Asker, Muntecep Yaman, Mehmet Babat, Naci Soyoral, Yasemin Cegin, Muhammed Bilal Gur, Ali Kemal Gumrukcuoglu, Hasan Ali |
author_sort | Akdag, Serkan |
collection | PubMed |
description | BACKGROUND: End stage renal disease is related to increased cardiovascular mortality and morbidity. Hypertension is an important risk factor for cardiovascular disorder among hemodialysis (HD) patients. The aim of this study was to investigate the effect of low-sodium dialysate on the systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels detected by ambulatory BP monitoring (ABPM) and interdialytic weight gain (IDWG) in patients undergoing sustained HD treatment. PATIENTS AND METHODS: The study included 46 patients who had creatinine clearance levels less than 10 mL/min/1.73 m(2) and had been on chronic HD treatment for at least 1 year. After the enrollment stage, the patients were allocated low-sodium dialysate or standard sodium dialysate for 6 months via computer-generated randomization. RESULTS: Twenty-four hour SBP, daytime SBP, nighttime SBP, and nighttime DBP were significantly decreased in the low-sodium dialysate group (P<0.05). No significant reduction was observed in both groups in terms of 24-hour DBP and daytime DBP (P=NS). No difference was found in the standard sodium dialysate group in terms of ABPM. Furthermore, IDWG was found to be significantly decreased in the low-sodium dialysate group after 6 months (P<0.001). CONCLUSION: The study revealed that low-sodium dialysate leads to a decrease in ABPM parameters including 24-hour SBP, daytime SBP, nighttime SBP, and nighttime DBP and it also reduces the number of antihypertensive drugs used and IDWG. |
format | Online Article Text |
id | pubmed-4685887 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-46858872015-12-29 The effect of low-sodium dialysate on ambulatory blood pressure measurement parameters in patients undergoing hemodialysis Akdag, Serkan Akyol, Aytac Cakmak, Huseyin Altug Tosu, Aydin Rodi Asker, Muntecep Yaman, Mehmet Babat, Naci Soyoral, Yasemin Cegin, Muhammed Bilal Gur, Ali Kemal Gumrukcuoglu, Hasan Ali Ther Clin Risk Manag Original Research BACKGROUND: End stage renal disease is related to increased cardiovascular mortality and morbidity. Hypertension is an important risk factor for cardiovascular disorder among hemodialysis (HD) patients. The aim of this study was to investigate the effect of low-sodium dialysate on the systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels detected by ambulatory BP monitoring (ABPM) and interdialytic weight gain (IDWG) in patients undergoing sustained HD treatment. PATIENTS AND METHODS: The study included 46 patients who had creatinine clearance levels less than 10 mL/min/1.73 m(2) and had been on chronic HD treatment for at least 1 year. After the enrollment stage, the patients were allocated low-sodium dialysate or standard sodium dialysate for 6 months via computer-generated randomization. RESULTS: Twenty-four hour SBP, daytime SBP, nighttime SBP, and nighttime DBP were significantly decreased in the low-sodium dialysate group (P<0.05). No significant reduction was observed in both groups in terms of 24-hour DBP and daytime DBP (P=NS). No difference was found in the standard sodium dialysate group in terms of ABPM. Furthermore, IDWG was found to be significantly decreased in the low-sodium dialysate group after 6 months (P<0.001). CONCLUSION: The study revealed that low-sodium dialysate leads to a decrease in ABPM parameters including 24-hour SBP, daytime SBP, nighttime SBP, and nighttime DBP and it also reduces the number of antihypertensive drugs used and IDWG. Dove Medical Press 2015-12-11 /pmc/articles/PMC4685887/ /pubmed/26715849 http://dx.doi.org/10.2147/TCRM.S94889 Text en © 2015 Akdag et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Akdag, Serkan Akyol, Aytac Cakmak, Huseyin Altug Tosu, Aydin Rodi Asker, Muntecep Yaman, Mehmet Babat, Naci Soyoral, Yasemin Cegin, Muhammed Bilal Gur, Ali Kemal Gumrukcuoglu, Hasan Ali The effect of low-sodium dialysate on ambulatory blood pressure measurement parameters in patients undergoing hemodialysis |
title | The effect of low-sodium dialysate on ambulatory blood pressure measurement parameters in patients undergoing hemodialysis |
title_full | The effect of low-sodium dialysate on ambulatory blood pressure measurement parameters in patients undergoing hemodialysis |
title_fullStr | The effect of low-sodium dialysate on ambulatory blood pressure measurement parameters in patients undergoing hemodialysis |
title_full_unstemmed | The effect of low-sodium dialysate on ambulatory blood pressure measurement parameters in patients undergoing hemodialysis |
title_short | The effect of low-sodium dialysate on ambulatory blood pressure measurement parameters in patients undergoing hemodialysis |
title_sort | effect of low-sodium dialysate on ambulatory blood pressure measurement parameters in patients undergoing hemodialysis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685887/ https://www.ncbi.nlm.nih.gov/pubmed/26715849 http://dx.doi.org/10.2147/TCRM.S94889 |
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