Cargando…

Catalytic asymmetric formal synthesis of beraprost

The first catalytic asymmetric synthesis of the key intermediate for beraprost has been achieved through an enantioselective intramolecular oxa-Michael reaction of an α,β-unsaturated amide mediated by a newly developed benzothiadiazine catalyst. The Weinreb amide moiety and bromo substituent of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kobayashi, Yusuke, Kuramoto, Ryuta, Takemoto, Yoshiji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2015
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685892/ https://www.ncbi.nlm.nih.gov/pubmed/26734111 http://dx.doi.org/10.3762/bjoc.11.285

Ejemplares similares

Catalytic Asymmetric Formal Total Synthesis of (−)-Triptophenolide and (+)-Triptolide
por: Xu, Wen-Dan, et al.
Publicado: (2016)

De Novo Synthesis of Dihydrobenzofurans and Indolines and Its Application to a Modular, Asymmetric Synthesis of Beraprost
por: Wang, Ze-Shu, et al.
Publicado: (2023)

Mechanistic Insight into the Catalytic Promiscuity of Amine Dehydrogenases: Asymmetric Synthesis of Secondary and Primary Amines
por: Tseliou, Vasilis, et al.
Publicado: (2019)

Asymmetric Isothiourea-Catalysed Formal [3+2] Cycloadditions of Ammonium Enolates with Oxaziridines
por: Smith, Siobhan R, et al.
Publicado: (2015)

Atypical and Asymmetric 1,3‐P,N Ligands: Synthesis, Coordination and Catalytic Performance of Cycloiminophosphanes
por: Rong, Mark K., et al.
Publicado: (2021)

Cascade radical reaction of substrates with a carbon–carbon triple bond as a radical acceptor
por: Miyabe, Hideto, et al.
Publicado: (2013)

Catalytic Enantioselective Synthesis of Heterocyclic Vicinal Fluoroamines by Using Asymmetric Protonation: Method Development and Mechanistic Study
por: Ashford, Matthew W., et al.
Publicado: (2020)

Catalytic asymmetric tandem Friedel–Crafts alkylation/Michael addition reaction for the synthesis of highly functionalized chromans
por: Peng, Jiahuan, et al.
Publicado: (2013)

Construction of the Pentacyclic Core and Formal Total Synthesis of (rac)‐Renieramycin T
por: Kimura, Shinya, et al.
Publicado: (2018)

Alternaric acid: formal synthesis and related studies
por: Slade, Michael C, et al.
Publicado: (2013)

Catalytic Asymmetric Fluorination of Copper Carbene Complexes: Preparative Advances and a Mechanistic Rationale
por: Buchsteiner, Michael, et al.
Publicado: (2020)

Catalytic Asymmetric Synthesis of Both Enantiomers of 4‑Substituted 1,4-Dihydropyridines with the Use of Bifunctional Thiourea-Ammonium Salts Bearing Different Counterions
por: Yoshida, Kohzo, et al.
Publicado: (2010)

Catalytic Asymmetric Formal [3+2] Cycloaddition of Azoalkenes with 3-Vinylindoles: Synthesis of 2,3-Dihydropyrroles
por: Mei, Guang-Jian, et al.
Publicado: (2020)

Catalytic asymmetric synthesis /
Publicado: (2000)

The Diels‐Alder Approach towards Cannabinoid Derivatives and Formal Synthesis of Tetrahydrocannabinol (THC)
por: Hurrle, Thomas, et al.
Publicado: (2021)

Catalytic asymmetric oxo-Diels–Alder reactions with chiral atropisomeric biphenyl diols
por: Yeung, Chi-Tung, et al.
Publicado: (2019)

Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis
por: Rueping, Magnus, et al.
Publicado: (2012)

Formal synthesis of (−)-agelastatin A: an iron(II)-mediated cyclization strategy
por: Shigeoka, Daisuke, et al.
Publicado: (2013)

Atropisomeric [(diphosphine)Au(2)Cl(2)] Complexes and their Catalytic Activity Towards Asymmetric Cycloisomerisation of 1,6-Enynes
por: Barreiro, Elena M, et al.
Publicado: (2015)

Exploring the Catalytic Promiscuity of Phenolic Acid Decarboxylases: Asymmetric, 1,6‐Conjugate Addition of Nucleophiles Across 4‐Hydroxystyrene
por: Payer, Stefan E., et al.
Publicado: (2017)

Asymmetric synthesis of host-directed inhibitors of myxoviruses
por: Moore, Terry W, et al.
Publicado: (2013)

An asymmetric synthesis of all stereoisomers of piclavines A1-4 using an iterative asymmetric dihydroxylation
por: Saito, Yukako, et al.
Publicado: (2007)

Formal enantioconvergent substitution of alkyl halides via catalytic asymmetric photoredox radical coupling
por: Li, Jiangtao, et al.
Publicado: (2018)

Asymmetric Synthesis of 2,4,5-Trisubstituted Δ(2)-Thiazolines
por: Bengtsson, Christoffer, et al.
Publicado: (2013)

Versatile Visible‐Light‐Driven Synthesis of Asymmetrical Phosphines and Phosphonium Salts
por: Arockiam, Percia Beatrice, et al.
Publicado: (2020)

Chemoenzymatic Asymmetric Synthesis of Pyridine‐Based α‐Fluorinated Secondary Alcohols
por: Broese, Timo, et al.
Publicado: (2021)

A novel and practical asymmetric synthesis of dapoxetine hydrochloride
por: Zhu, Yijun, et al.
Publicado: (2015)

Asymmetric synthesis of propargylamines as amino acid surrogates in peptidomimetics
por: Wünsch, Matthias, et al.
Publicado: (2017)

A novel and practical asymmetric synthesis of eptazocine hydrobromide
por: Li, Ruipeng, et al.
Publicado: (2018)

Bifunctional organocatalysts for the asymmetric synthesis of axially chiral benzamides
por: Miyaji, Ryota, et al.
Publicado: (2017)

Electrochemically Synthesis of Nickel Cobalt Sulfide for High‐Performance Flexible Asymmetric Supercapacitors
por: Zhang, Chunyan, et al.
Publicado: (2017)

Application of Threonine Aldolases for the Asymmetric Synthesis of α‐Quaternary α‐Amino Acids
por: Blesl, Julia, et al.
Publicado: (2018)

Computational Design of Enantiocomplementary Epoxide Hydrolases for Asymmetric Synthesis of Aliphatic and Aromatic Diols
por: Arabnejad, Hesam, et al.
Publicado: (2020)

Asymmetric Synthesis of 2‐Arylindolines and 2,2‐Disubstituted Indolines by Kinetic Resolution
por: Choi, Anthony, et al.
Publicado: (2021)

Formal C−H Carboxylation of Unactivated Arenes
por: Gevorgyan, Ashot, et al.
Publicado: (2020)

Catalytic asymmetric synthesis of geminal-dicarboxylates
por: Mistry, Nisha, et al.
Publicado: (2018)

Catalytic Asymmetric Synthesis of Butenolides and Butyrolactones
por: Mao, Bin, et al.
Publicado: (2017)

Oxidative allylic rearrangement of cycloalkenols: Formal total synthesis of enantiomerically pure trisporic acid B
por: Dubberke, Silke, et al.
Publicado: (2011)

Beraprost and Overall Survival in Cats with Chronic Kidney Disease
por: Ito, Hiroyuki, et al.
Publicado: (2023)

Concise methods for the synthesis of chiral polyoxazolines and their application in asymmetric hydrosilylation
por: Li, Wei Jie, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_8o3596q189ul8r268m6243p2b4