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Biocatalysis for the application of CO(2) as a chemical feedstock
Biocatalysts, capable of efficiently transforming CO(2) into other more reduced forms of carbon, offer sustainable alternatives to current oxidative technologies that rely on diminishing natural fossil-fuel deposits. Enzymes that catalyse CO(2) fixation steps in carbon assimilation pathways are prom...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Beilstein-Institut
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685893/ https://www.ncbi.nlm.nih.gov/pubmed/26734087 http://dx.doi.org/10.3762/bjoc.11.259 |
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author | Alissandratos, Apostolos Easton, Christopher J |
author_facet | Alissandratos, Apostolos Easton, Christopher J |
author_sort | Alissandratos, Apostolos |
collection | PubMed |
description | Biocatalysts, capable of efficiently transforming CO(2) into other more reduced forms of carbon, offer sustainable alternatives to current oxidative technologies that rely on diminishing natural fossil-fuel deposits. Enzymes that catalyse CO(2) fixation steps in carbon assimilation pathways are promising catalysts for the sustainable transformation of this safe and renewable feedstock into central metabolites. These may be further converted into a wide range of fuels and commodity chemicals, through the multitude of known enzymatic reactions. The required reducing equivalents for the net carbon reductions may be drawn from solar energy, electricity or chemical oxidation, and delivered in vitro or through cellular mechanisms, while enzyme catalysis lowers the activation barriers of the CO(2) transformations to make them more energy efficient. The development of technologies that treat CO(2)-transforming enzymes and other cellular components as modules that may be assembled into synthetic reaction circuits will facilitate the use of CO(2) as a renewable chemical feedstock, greatly enabling a sustainable carbon bio-economy. |
format | Online Article Text |
id | pubmed-4685893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-46858932016-01-05 Biocatalysis for the application of CO(2) as a chemical feedstock Alissandratos, Apostolos Easton, Christopher J Beilstein J Org Chem Review Biocatalysts, capable of efficiently transforming CO(2) into other more reduced forms of carbon, offer sustainable alternatives to current oxidative technologies that rely on diminishing natural fossil-fuel deposits. Enzymes that catalyse CO(2) fixation steps in carbon assimilation pathways are promising catalysts for the sustainable transformation of this safe and renewable feedstock into central metabolites. These may be further converted into a wide range of fuels and commodity chemicals, through the multitude of known enzymatic reactions. The required reducing equivalents for the net carbon reductions may be drawn from solar energy, electricity or chemical oxidation, and delivered in vitro or through cellular mechanisms, while enzyme catalysis lowers the activation barriers of the CO(2) transformations to make them more energy efficient. The development of technologies that treat CO(2)-transforming enzymes and other cellular components as modules that may be assembled into synthetic reaction circuits will facilitate the use of CO(2) as a renewable chemical feedstock, greatly enabling a sustainable carbon bio-economy. Beilstein-Institut 2015-12-01 /pmc/articles/PMC4685893/ /pubmed/26734087 http://dx.doi.org/10.3762/bjoc.11.259 Text en Copyright © 2015, Alissandratos and Easton https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
spellingShingle | Review Alissandratos, Apostolos Easton, Christopher J Biocatalysis for the application of CO(2) as a chemical feedstock |
title | Biocatalysis for the application of CO(2) as a chemical feedstock |
title_full | Biocatalysis for the application of CO(2) as a chemical feedstock |
title_fullStr | Biocatalysis for the application of CO(2) as a chemical feedstock |
title_full_unstemmed | Biocatalysis for the application of CO(2) as a chemical feedstock |
title_short | Biocatalysis for the application of CO(2) as a chemical feedstock |
title_sort | biocatalysis for the application of co(2) as a chemical feedstock |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685893/ https://www.ncbi.nlm.nih.gov/pubmed/26734087 http://dx.doi.org/10.3762/bjoc.11.259 |
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