Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar

The synthesis of new multivalent architectures based on a trihydroxypiperidine α-fucosidase inhibitor is reported herein. Tetravalent and nonavalent dendrimers were obtained by means of the click chemistry approach involving the copper azide-alkyne-catalyzed cycloaddition (CuAAC) between suitable sc...

Descripción completa

Detalles Bibliográficos
Autores principales: Matassini, Camilla, Mirabella, Stefania, Goti, Andrea, Robina, Inmaculada, Moreno-Vargas, Antonio J, Cardona, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2015
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685925/
https://www.ncbi.nlm.nih.gov/pubmed/26734108
http://dx.doi.org/10.3762/bjoc.11.282
_version_ 1782406376451997696
author Matassini, Camilla
Mirabella, Stefania
Goti, Andrea
Robina, Inmaculada
Moreno-Vargas, Antonio J
Cardona, Francesca
author_facet Matassini, Camilla
Mirabella, Stefania
Goti, Andrea
Robina, Inmaculada
Moreno-Vargas, Antonio J
Cardona, Francesca
author_sort Matassini, Camilla
collection PubMed
description The synthesis of new multivalent architectures based on a trihydroxypiperidine α-fucosidase inhibitor is reported herein. Tetravalent and nonavalent dendrimers were obtained by means of the click chemistry approach involving the copper azide-alkyne-catalyzed cycloaddition (CuAAC) between suitable scaffolds bearing terminal alkyne moieties and an azido-functionalized piperidine as the bioactive moiety. A preliminary biological investigation is also reported towards commercially available and human glycosidases.
format Online
Article
Text
id pubmed-4685925
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Beilstein-Institut
record_format MEDLINE/PubMed
spelling pubmed-46859252016-01-05 Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar Matassini, Camilla Mirabella, Stefania Goti, Andrea Robina, Inmaculada Moreno-Vargas, Antonio J Cardona, Francesca Beilstein J Org Chem Full Research Paper The synthesis of new multivalent architectures based on a trihydroxypiperidine α-fucosidase inhibitor is reported herein. Tetravalent and nonavalent dendrimers were obtained by means of the click chemistry approach involving the copper azide-alkyne-catalyzed cycloaddition (CuAAC) between suitable scaffolds bearing terminal alkyne moieties and an azido-functionalized piperidine as the bioactive moiety. A preliminary biological investigation is also reported towards commercially available and human glycosidases. Beilstein-Institut 2015-12-16 /pmc/articles/PMC4685925/ /pubmed/26734108 http://dx.doi.org/10.3762/bjoc.11.282 Text en Copyright © 2015, Matassini et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Matassini, Camilla
Mirabella, Stefania
Goti, Andrea
Robina, Inmaculada
Moreno-Vargas, Antonio J
Cardona, Francesca
Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
title Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
title_full Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
title_fullStr Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
title_full_unstemmed Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
title_short Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
title_sort exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685925/
https://www.ncbi.nlm.nih.gov/pubmed/26734108
http://dx.doi.org/10.3762/bjoc.11.282
work_keys_str_mv AT matassinicamilla exploringarchitecturesdisplayingmultimericpresentationsofatrihydroxypiperidineiminosugar
AT mirabellastefania exploringarchitecturesdisplayingmultimericpresentationsofatrihydroxypiperidineiminosugar
AT gotiandrea exploringarchitecturesdisplayingmultimericpresentationsofatrihydroxypiperidineiminosugar
AT robinainmaculada exploringarchitecturesdisplayingmultimericpresentationsofatrihydroxypiperidineiminosugar
AT morenovargasantonioj exploringarchitecturesdisplayingmultimericpresentationsofatrihydroxypiperidineiminosugar
AT cardonafrancesca exploringarchitecturesdisplayingmultimericpresentationsofatrihydroxypiperidineiminosugar

Ejemplares similares