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Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington’s Disease

Huntington’s disease is the result of a long polyglutamine tract in the gene encoding huntingtin protein, which in turn causes a large number of cellular changes and ultimately results in neurodegeneration of striatal neurons. Although many theories have been proposed, the precise mechanism by which...

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Detalles Bibliográficos
Autores principales:	Dasgupta, Sayani, Fishman, Michael A., Mahallati, Hana, Castro, Leandro M., Tashima, Alexandre K., Ferro, Emer S., Fricker, Lloyd D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686214/ https://www.ncbi.nlm.nih.gov/pubmed/26691307 http://dx.doi.org/10.1371/journal.pone.0145333

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