Cargando…
Cost-Effectiveness of HBV and HCV Screening Strategies – A Systematic Review of Existing Modelling Techniques
INTRODUCTION: Studies evaluating the cost-effectiveness of screening for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are generally heterogeneous in terms of risk groups, settings, screening intervention, outcomes and the economic modelling framework. It is therefore difficult to compare cost...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686364/ https://www.ncbi.nlm.nih.gov/pubmed/26689908 http://dx.doi.org/10.1371/journal.pone.0145022 |
_version_ | 1782406430377115648 |
---|---|
author | Geue, Claudia Wu, Olivia Xin, Yiqiao Heggie, Robert Hutchinson, Sharon Martin, Natasha K. Fenwick, Elisabeth Goldberg, David |
author_facet | Geue, Claudia Wu, Olivia Xin, Yiqiao Heggie, Robert Hutchinson, Sharon Martin, Natasha K. Fenwick, Elisabeth Goldberg, David |
author_sort | Geue, Claudia |
collection | PubMed |
description | INTRODUCTION: Studies evaluating the cost-effectiveness of screening for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are generally heterogeneous in terms of risk groups, settings, screening intervention, outcomes and the economic modelling framework. It is therefore difficult to compare cost-effectiveness results between studies. This systematic review aims to summarise and critically assess existing economic models for HBV and HCV in order to identify the main methodological differences in modelling approaches. METHODS: A structured search strategy was developed and a systematic review carried out. A critical assessment of the decision-analytic models was carried out according to the guidelines and framework developed for assessment of decision-analytic models in Health Technology Assessment of health care interventions. RESULTS: The overall approach to analysing the cost-effectiveness of screening strategies was found to be broadly consistent for HBV and HCV. However, modelling parameters and related structure differed between models, producing different results. More recent publications performed better against a performance matrix, evaluating model components and methodology. CONCLUSION: When assessing screening strategies for HBV and HCV infection, the focus should be on more recent studies, which applied the latest treatment regimes, test methods and had better and more complete data on which to base their models. In addition to parameter selection and associated assumptions, careful consideration of dynamic versus static modelling is recommended. Future research may want to focus on these methodological issues. In addition, the ability to evaluate screening strategies for multiple infectious diseases, (HCV and HIV at the same time) might prove important for decision makers. |
format | Online Article Text |
id | pubmed-4686364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-46863642016-01-07 Cost-Effectiveness of HBV and HCV Screening Strategies – A Systematic Review of Existing Modelling Techniques Geue, Claudia Wu, Olivia Xin, Yiqiao Heggie, Robert Hutchinson, Sharon Martin, Natasha K. Fenwick, Elisabeth Goldberg, David PLoS One Research Article INTRODUCTION: Studies evaluating the cost-effectiveness of screening for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are generally heterogeneous in terms of risk groups, settings, screening intervention, outcomes and the economic modelling framework. It is therefore difficult to compare cost-effectiveness results between studies. This systematic review aims to summarise and critically assess existing economic models for HBV and HCV in order to identify the main methodological differences in modelling approaches. METHODS: A structured search strategy was developed and a systematic review carried out. A critical assessment of the decision-analytic models was carried out according to the guidelines and framework developed for assessment of decision-analytic models in Health Technology Assessment of health care interventions. RESULTS: The overall approach to analysing the cost-effectiveness of screening strategies was found to be broadly consistent for HBV and HCV. However, modelling parameters and related structure differed between models, producing different results. More recent publications performed better against a performance matrix, evaluating model components and methodology. CONCLUSION: When assessing screening strategies for HBV and HCV infection, the focus should be on more recent studies, which applied the latest treatment regimes, test methods and had better and more complete data on which to base their models. In addition to parameter selection and associated assumptions, careful consideration of dynamic versus static modelling is recommended. Future research may want to focus on these methodological issues. In addition, the ability to evaluate screening strategies for multiple infectious diseases, (HCV and HIV at the same time) might prove important for decision makers. Public Library of Science 2015-12-21 /pmc/articles/PMC4686364/ /pubmed/26689908 http://dx.doi.org/10.1371/journal.pone.0145022 Text en © 2015 Geue et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Geue, Claudia Wu, Olivia Xin, Yiqiao Heggie, Robert Hutchinson, Sharon Martin, Natasha K. Fenwick, Elisabeth Goldberg, David Cost-Effectiveness of HBV and HCV Screening Strategies – A Systematic Review of Existing Modelling Techniques |
title | Cost-Effectiveness of HBV and HCV Screening Strategies – A Systematic Review of Existing Modelling Techniques |
title_full | Cost-Effectiveness of HBV and HCV Screening Strategies – A Systematic Review of Existing Modelling Techniques |
title_fullStr | Cost-Effectiveness of HBV and HCV Screening Strategies – A Systematic Review of Existing Modelling Techniques |
title_full_unstemmed | Cost-Effectiveness of HBV and HCV Screening Strategies – A Systematic Review of Existing Modelling Techniques |
title_short | Cost-Effectiveness of HBV and HCV Screening Strategies – A Systematic Review of Existing Modelling Techniques |
title_sort | cost-effectiveness of hbv and hcv screening strategies – a systematic review of existing modelling techniques |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686364/ https://www.ncbi.nlm.nih.gov/pubmed/26689908 http://dx.doi.org/10.1371/journal.pone.0145022 |
work_keys_str_mv | AT geueclaudia costeffectivenessofhbvandhcvscreeningstrategiesasystematicreviewofexistingmodellingtechniques AT wuolivia costeffectivenessofhbvandhcvscreeningstrategiesasystematicreviewofexistingmodellingtechniques AT xinyiqiao costeffectivenessofhbvandhcvscreeningstrategiesasystematicreviewofexistingmodellingtechniques AT heggierobert costeffectivenessofhbvandhcvscreeningstrategiesasystematicreviewofexistingmodellingtechniques AT hutchinsonsharon costeffectivenessofhbvandhcvscreeningstrategiesasystematicreviewofexistingmodellingtechniques AT martinnatashak costeffectivenessofhbvandhcvscreeningstrategiesasystematicreviewofexistingmodellingtechniques AT fenwickelisabeth costeffectivenessofhbvandhcvscreeningstrategiesasystematicreviewofexistingmodellingtechniques AT goldbergdavid costeffectivenessofhbvandhcvscreeningstrategiesasystematicreviewofexistingmodellingtechniques AT costeffectivenessofhbvandhcvscreeningstrategiesasystematicreviewofexistingmodellingtechniques |