Acquisition of Full-Length Viral Helicase Domains by Insect Retrotransposon-Encoded Polypeptides

Recent metagenomic studies in insects identified many sequences unexpectedly closely related to plant virus genes. Here we describe a new example of this kind, insect R1 LINEs with an additional C-terminal domain in their open reading frame 2. This domain is similar to NTPase/helicase (SF1H) domains...

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Autores principales: Lazareva, Ekaterina, Lezzhov, Alexander, Vassetzky, Nikita, Solovyev, Andrey, Morozov, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686597/
https://www.ncbi.nlm.nih.gov/pubmed/26733982
http://dx.doi.org/10.3389/fmicb.2015.01447
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author Lazareva, Ekaterina
Lezzhov, Alexander
Vassetzky, Nikita
Solovyev, Andrey
Morozov, Sergey
author_facet Lazareva, Ekaterina
Lezzhov, Alexander
Vassetzky, Nikita
Solovyev, Andrey
Morozov, Sergey
author_sort Lazareva, Ekaterina
collection PubMed
description Recent metagenomic studies in insects identified many sequences unexpectedly closely related to plant virus genes. Here we describe a new example of this kind, insect R1 LINEs with an additional C-terminal domain in their open reading frame 2. This domain is similar to NTPase/helicase (SF1H) domains, which are found in replicative proteins encoded by plant viruses of the genus Tobamovirus. We hypothesize that the SF1H domain could be acquired by LINEs, directly or indirectly, upon insect feeding on virus-infected plants. Possible functions of this domain in LINE transposition and involvement in LINEs counteraction the silencing-based cell defense against retrotransposons are discussed.
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spelling pubmed-46865972016-01-05 Acquisition of Full-Length Viral Helicase Domains by Insect Retrotransposon-Encoded Polypeptides Lazareva, Ekaterina Lezzhov, Alexander Vassetzky, Nikita Solovyev, Andrey Morozov, Sergey Front Microbiol Microbiology Recent metagenomic studies in insects identified many sequences unexpectedly closely related to plant virus genes. Here we describe a new example of this kind, insect R1 LINEs with an additional C-terminal domain in their open reading frame 2. This domain is similar to NTPase/helicase (SF1H) domains, which are found in replicative proteins encoded by plant viruses of the genus Tobamovirus. We hypothesize that the SF1H domain could be acquired by LINEs, directly or indirectly, upon insect feeding on virus-infected plants. Possible functions of this domain in LINE transposition and involvement in LINEs counteraction the silencing-based cell defense against retrotransposons are discussed. Frontiers Media S.A. 2015-12-22 /pmc/articles/PMC4686597/ /pubmed/26733982 http://dx.doi.org/10.3389/fmicb.2015.01447 Text en Copyright © 2015 Lazareva, Lezzhov, Vassetzky, Solovyev and Morozov. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Lazareva, Ekaterina
Lezzhov, Alexander
Vassetzky, Nikita
Solovyev, Andrey
Morozov, Sergey
Acquisition of Full-Length Viral Helicase Domains by Insect Retrotransposon-Encoded Polypeptides
title Acquisition of Full-Length Viral Helicase Domains by Insect Retrotransposon-Encoded Polypeptides
title_full Acquisition of Full-Length Viral Helicase Domains by Insect Retrotransposon-Encoded Polypeptides
title_fullStr Acquisition of Full-Length Viral Helicase Domains by Insect Retrotransposon-Encoded Polypeptides
title_full_unstemmed Acquisition of Full-Length Viral Helicase Domains by Insect Retrotransposon-Encoded Polypeptides
title_short Acquisition of Full-Length Viral Helicase Domains by Insect Retrotransposon-Encoded Polypeptides
title_sort acquisition of full-length viral helicase domains by insect retrotransposon-encoded polypeptides
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686597/
https://www.ncbi.nlm.nih.gov/pubmed/26733982
http://dx.doi.org/10.3389/fmicb.2015.01447
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