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Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease
Ketamine is reported to be an effective adjuvant to opioids in the treatment of refractory cancer pain; however, the use of high doses of ketamine for extended periods in pediatric patients has not been described. We present a five-year-old male with grade IV intestinal GVHD whose abdominal pain req...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686632/ https://www.ncbi.nlm.nih.gov/pubmed/26779350 http://dx.doi.org/10.1155/2015/834168 |
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author | Busse, Jennifer Phillips, Leroy Schechter, William |
author_facet | Busse, Jennifer Phillips, Leroy Schechter, William |
author_sort | Busse, Jennifer |
collection | PubMed |
description | Ketamine is reported to be an effective adjuvant to opioids in the treatment of refractory cancer pain; however, the use of high doses of ketamine for extended periods in pediatric patients has not been described. We present a five-year-old male with grade IV intestinal GVHD whose abdominal pain required both hydromorphone and ketamine for a period of over four months. There was no evidence of hepatotoxicity, hemorrhagic cystitis, or other adverse effects. Possible withdrawal symptoms were mild and were readily mitigated by gradually weaning ketamine. |
format | Online Article Text |
id | pubmed-4686632 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46866322016-01-17 Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease Busse, Jennifer Phillips, Leroy Schechter, William Case Rep Anesthesiol Case Report Ketamine is reported to be an effective adjuvant to opioids in the treatment of refractory cancer pain; however, the use of high doses of ketamine for extended periods in pediatric patients has not been described. We present a five-year-old male with grade IV intestinal GVHD whose abdominal pain required both hydromorphone and ketamine for a period of over four months. There was no evidence of hepatotoxicity, hemorrhagic cystitis, or other adverse effects. Possible withdrawal symptoms were mild and were readily mitigated by gradually weaning ketamine. Hindawi Publishing Corporation 2015 2015-12-08 /pmc/articles/PMC4686632/ /pubmed/26779350 http://dx.doi.org/10.1155/2015/834168 Text en Copyright © 2015 Jennifer Busse et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Busse, Jennifer Phillips, Leroy Schechter, William Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease |
title | Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease |
title_full | Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease |
title_fullStr | Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease |
title_full_unstemmed | Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease |
title_short | Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease |
title_sort | long-term intravenous ketamine for analgesia in a child with severe chronic intestinal graft versus host disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686632/ https://www.ncbi.nlm.nih.gov/pubmed/26779350 http://dx.doi.org/10.1155/2015/834168 |
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