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Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease

Ketamine is reported to be an effective adjuvant to opioids in the treatment of refractory cancer pain; however, the use of high doses of ketamine for extended periods in pediatric patients has not been described. We present a five-year-old male with grade IV intestinal GVHD whose abdominal pain req...

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Detalles Bibliográficos
Autores principales: Busse, Jennifer, Phillips, Leroy, Schechter, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686632/
https://www.ncbi.nlm.nih.gov/pubmed/26779350
http://dx.doi.org/10.1155/2015/834168
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author Busse, Jennifer
Phillips, Leroy
Schechter, William
author_facet Busse, Jennifer
Phillips, Leroy
Schechter, William
author_sort Busse, Jennifer
collection PubMed
description Ketamine is reported to be an effective adjuvant to opioids in the treatment of refractory cancer pain; however, the use of high doses of ketamine for extended periods in pediatric patients has not been described. We present a five-year-old male with grade IV intestinal GVHD whose abdominal pain required both hydromorphone and ketamine for a period of over four months. There was no evidence of hepatotoxicity, hemorrhagic cystitis, or other adverse effects. Possible withdrawal symptoms were mild and were readily mitigated by gradually weaning ketamine.
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spelling pubmed-46866322016-01-17 Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease Busse, Jennifer Phillips, Leroy Schechter, William Case Rep Anesthesiol Case Report Ketamine is reported to be an effective adjuvant to opioids in the treatment of refractory cancer pain; however, the use of high doses of ketamine for extended periods in pediatric patients has not been described. We present a five-year-old male with grade IV intestinal GVHD whose abdominal pain required both hydromorphone and ketamine for a period of over four months. There was no evidence of hepatotoxicity, hemorrhagic cystitis, or other adverse effects. Possible withdrawal symptoms were mild and were readily mitigated by gradually weaning ketamine. Hindawi Publishing Corporation 2015 2015-12-08 /pmc/articles/PMC4686632/ /pubmed/26779350 http://dx.doi.org/10.1155/2015/834168 Text en Copyright © 2015 Jennifer Busse et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Busse, Jennifer
Phillips, Leroy
Schechter, William
Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease
title Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease
title_full Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease
title_fullStr Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease
title_full_unstemmed Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease
title_short Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease
title_sort long-term intravenous ketamine for analgesia in a child with severe chronic intestinal graft versus host disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686632/
https://www.ncbi.nlm.nih.gov/pubmed/26779350
http://dx.doi.org/10.1155/2015/834168
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