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Insulin-like growth factor (IGF)-I obliterates the pregnancy-associated protection against mammary carcinogenesis in rats: evidence that IGF-I enhances cancer progression through estrogen receptor-α activation via the mitogen-activated protein kinase pathway

INTRODUCTION: Pregnancy protects against breast cancer development in humans and rats. Parous rats have persistently reduced circulating levels of growth hormone, which may affect the activity of the growth hormone/insulin-like growth factor (IGF)-I axis. We investigated the effects of IGF-I on pari...

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Detalles Bibliográficos
Autores principales:	Thordarson, Gudmundur, Slusher, Nicole, Leong, Harriet, Ochoa, Dafne, Rajkumar, Lakshmanaswamy, Guzman, Raphael, Nandi, Satyabrata, Talamantes, Frank
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2004
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC468665/ https://www.ncbi.nlm.nih.gov/pubmed/15217511 http://dx.doi.org/10.1186/bcr812

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