Branched-chain amino acid catabolism is a conserved regulator of physiological ageing

Ageing has been defined as a global decline in physiological function depending on both environmental and genetic factors. Here we identify gene transcripts that are similarly regulated during physiological ageing in nematodes, zebrafish and mice. We observe the strongest extension of lifespan when...

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Detalles Bibliográficos
Autores principales: Mansfeld, Johannes, Urban, Nadine, Priebe, Steffen, Groth, Marco, Frahm, Christiane, Hartmann, Nils, Gebauer, Juliane, Ravichandran, Meenakshi, Dommaschk, Anne, Schmeisser, Sebastian, Kuhlow, Doreen, Monajembashi, Shamci, Bremer-Streck, Sibylle, Hemmerich, Peter, Kiehntopf, Michael, Zamboni, Nicola, Englert, Christoph, Guthke, Reinhard, Kaleta, Christoph, Platzer, Matthias, Sühnel, Jürgen, Witte, Otto W., Zarse, Kim, Ristow, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686672/
https://www.ncbi.nlm.nih.gov/pubmed/26620638
http://dx.doi.org/10.1038/ncomms10043

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