The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance

Mammalian target of rapamycin (mTOR) controls cell growth and metabolism in response to nutrients, energy, and growth factors. Recent findings have placed the lysosome at the core of mTOR complex 1 (mTORC1) regulation by amino acids. Two parallel pathways, Rag GTPase-Ragulator and Vps34-phospholipas...

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Autores principales: Yoon, Mee-Sup, Choi, Cheol Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686696/
https://www.ncbi.nlm.nih.gov/pubmed/27534530
http://dx.doi.org/10.1038/emm.2015.93
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author Yoon, Mee-Sup
Choi, Cheol Soo
author_facet Yoon, Mee-Sup
Choi, Cheol Soo
author_sort Yoon, Mee-Sup
collection PubMed
description Mammalian target of rapamycin (mTOR) controls cell growth and metabolism in response to nutrients, energy, and growth factors. Recent findings have placed the lysosome at the core of mTOR complex 1 (mTORC1) regulation by amino acids. Two parallel pathways, Rag GTPase-Ragulator and Vps34-phospholipase D1 (PLD1), regulate mTOR activation on the lysosome. This review describes the recent advances in understanding amino acid-induced mTOR signaling with a particular focus on the role of mTOR in insulin resistance.
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spelling pubmed-46866962015-12-30 The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance Yoon, Mee-Sup Choi, Cheol Soo Exp Mol Med Review Mammalian target of rapamycin (mTOR) controls cell growth and metabolism in response to nutrients, energy, and growth factors. Recent findings have placed the lysosome at the core of mTOR complex 1 (mTORC1) regulation by amino acids. Two parallel pathways, Rag GTPase-Ragulator and Vps34-phospholipase D1 (PLD1), regulate mTOR activation on the lysosome. This review describes the recent advances in understanding amino acid-induced mTOR signaling with a particular focus on the role of mTOR in insulin resistance. Nature Publishing Group 2016-01 2016-01-08 /pmc/articles/PMC4686696/ /pubmed/27534530 http://dx.doi.org/10.1038/emm.2015.93 Text en Copyright © 2016 KSBMB. http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Review
Yoon, Mee-Sup
Choi, Cheol Soo
The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance
title The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance
title_full The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance
title_fullStr The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance
title_full_unstemmed The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance
title_short The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance
title_sort role of amino acid-induced mammalian target of rapamycin complex 1(mtorc1) signaling in insulin resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686696/
https://www.ncbi.nlm.nih.gov/pubmed/27534530
http://dx.doi.org/10.1038/emm.2015.93
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