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The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance
Mammalian target of rapamycin (mTOR) controls cell growth and metabolism in response to nutrients, energy, and growth factors. Recent findings have placed the lysosome at the core of mTOR complex 1 (mTORC1) regulation by amino acids. Two parallel pathways, Rag GTPase-Ragulator and Vps34-phospholipas...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686696/ https://www.ncbi.nlm.nih.gov/pubmed/27534530 http://dx.doi.org/10.1038/emm.2015.93 |