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Structural insights into the DNA-binding specificity of E2F family transcription factors

The mammalian cell cycle is controlled by the E2F family of transcription factors. Typical E2Fs bind to DNA as heterodimers with the related dimerization partner (DP) proteins, whereas the atypical E2Fs, E2F7 and E2F8 contain two DNA-binding domains (DBDs) and act as repressors. To understand the me...

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Detalles Bibliográficos
Autores principales:	Morgunova, Ekaterina, Yin, Yimeng, Jolma, Arttu, Dave, Kashyap, Schmierer, Bernhard, Popov, Alexander, Eremina, Nadejda, Nilsson, Lennart, Taipale, Jussi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686757/ https://www.ncbi.nlm.nih.gov/pubmed/26632596 http://dx.doi.org/10.1038/ncomms10050

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