PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

PTEN is a tumour suppressor frequently mutated in many types of cancers. Here we show that targeted disruption of PTEN leads to neoplastic transformation of human neural stem cells (NSCs), but not mesenchymal stem cells. PTEN-deficient NSCs display neoplasm-associated metabolic and gene expression p...

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Detalles Bibliográficos
Autores principales: Duan, Shunlei, Yuan, Guohong, Liu, Xiaomeng, Ren, Ruotong, Li, Jingyi, Zhang, Weizhou, Wu, Jun, Xu, Xiuling, Fu, Lina, Li, Ying, Yang, Jiping, Zhang, Weiqi, Bai, Ruijun, Yi, Fei, Suzuki, Keiichiro, Gao, Hua, Esteban, Concepcion Rodriguez, Zhang, Chuanbao, Belmonte, Juan Carlos Izpisua, Chen, Zhiguo, Wang, Xiaomin, Jiang, Tao, Qu, Jing, Tang, Fuchou, Liu, Guang-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686761/
https://www.ncbi.nlm.nih.gov/pubmed/26632666
http://dx.doi.org/10.1038/ncomms10068

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