Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency

Osteosarcomas are aggressive bone tumours with a high degree of genetic heterogeneity, which has historically complicated driver gene discovery. Here we sequence exomes of 31 tumours and decipher their evolutionary landscape by inferring clonality of the individual mutation events. Exome findings ar...

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Detalles Bibliográficos
Autores principales: Kovac, Michal, Blattmann, Claudia, Ribi, Sebastian, Smida, Jan, Mueller, Nikola S., Engert, Florian, Castro-Giner, Francesc, Weischenfeldt, Joachim, Kovacova, Monika, Krieg, Andreas, Andreou, Dimosthenis, Tunn, Per-Ulf, Dürr, Hans Roland, Rechl, Hans, Schaser, Klaus-Dieter, Melcher, Ingo, Burdach, Stefan, Kulozik, Andreas, Specht, Katja, Heinimann, Karl, Fulda, Simone, Bielack, Stefan, Jundt, Gernot, Tomlinson, Ian, Korbel, Jan O., Nathrath, Michaela, Baumhoer, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686819/
https://www.ncbi.nlm.nih.gov/pubmed/26632267
http://dx.doi.org/10.1038/ncomms9940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686819/
https://www.ncbi.nlm.nih.gov/pubmed/26632267
http://dx.doi.org/10.1038/ncomms9940

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