Cargando…
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC) and FEV(1)/FVC with 1000 Genomes Project (phase 1)-imputed g...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686825/ https://www.ncbi.nlm.nih.gov/pubmed/26635082 http://dx.doi.org/10.1038/ncomms9658 |
| _version_ | 1782406506791043072 |
|---|---|
| author | Artigas, María Soler Wain, Louise V. Miller, Suzanne Kheirallah, Abdul Kader Huffman, Jennifer E. Ntalla, Ioanna Shrine, Nick Obeidat, Ma'en Trochet, Holly McArdle, Wendy L. Alves, Alexessander Couto Hui, Jennie Zhao, Jing Hua Joshi, Peter K. Teumer, Alexander Albrecht, Eva Imboden, Medea Rawal, Rajesh Lopez, Lorna M. Marten, Jonathan Enroth, Stefan Surakka, Ida Polasek, Ozren Lyytikäinen, Leo-Pekka Granell, Raquel Hysi, Pirro G. Flexeder, Claudia Mahajan, Anubha Beilby, John Bossé, Yohan Brandsma, Corry-Anke Campbell, Harry Gieger, Christian Gläser, Sven González, Juan R. Grallert, Harald Hammond, Chris J. Harris, Sarah E. Hartikainen, Anna-Liisa Heliövaara, Markku Henderson, John Hocking, Lynne Horikoshi, Momoko Hutri-Kähönen, Nina Ingelsson, Erik Johansson, Åsa Kemp, John P. Kolcic, Ivana Kumar, Ashish Lind, Lars Melén, Erik Musk, Arthur W. Navarro, Pau Nickle, David C. Padmanabhan, Sandosh Raitakari, Olli T. Ried, Janina S. Ripatti, Samuli Schulz, Holger Scott, Robert A. Sin, Don D. Starr, John M. Viñuela, Ana Völzke, Henry Wild, Sarah H. Wright, Alan F. Zemunik, Tatijana Jarvis, Deborah L. Spector, Tim D. Evans, David M. Lehtimäki, Terho Vitart, Veronique Kähönen, Mika Gyllensten, Ulf Rudan, Igor Deary, Ian J. Karrasch, Stefan Probst-Hensch, Nicole M. Heinrich, Joachim Stubbe, Beate Wilson, James F. Wareham, Nicholas J. James, Alan L. Morris, Andrew P. Jarvelin, Marjo-Riitta Hayward, Caroline Sayers, Ian Strachan, David P. Hall, Ian P. Tobin, Martin D. |
| author_facet | Artigas, María Soler Wain, Louise V. Miller, Suzanne Kheirallah, Abdul Kader Huffman, Jennifer E. Ntalla, Ioanna Shrine, Nick Obeidat, Ma'en Trochet, Holly McArdle, Wendy L. Alves, Alexessander Couto Hui, Jennie Zhao, Jing Hua Joshi, Peter K. Teumer, Alexander Albrecht, Eva Imboden, Medea Rawal, Rajesh Lopez, Lorna M. Marten, Jonathan Enroth, Stefan Surakka, Ida Polasek, Ozren Lyytikäinen, Leo-Pekka Granell, Raquel Hysi, Pirro G. Flexeder, Claudia Mahajan, Anubha Beilby, John Bossé, Yohan Brandsma, Corry-Anke Campbell, Harry Gieger, Christian Gläser, Sven González, Juan R. Grallert, Harald Hammond, Chris J. Harris, Sarah E. Hartikainen, Anna-Liisa Heliövaara, Markku Henderson, John Hocking, Lynne Horikoshi, Momoko Hutri-Kähönen, Nina Ingelsson, Erik Johansson, Åsa Kemp, John P. Kolcic, Ivana Kumar, Ashish Lind, Lars Melén, Erik Musk, Arthur W. Navarro, Pau Nickle, David C. Padmanabhan, Sandosh Raitakari, Olli T. Ried, Janina S. Ripatti, Samuli Schulz, Holger Scott, Robert A. Sin, Don D. Starr, John M. Viñuela, Ana Völzke, Henry Wild, Sarah H. Wright, Alan F. Zemunik, Tatijana Jarvis, Deborah L. Spector, Tim D. Evans, David M. Lehtimäki, Terho Vitart, Veronique Kähönen, Mika Gyllensten, Ulf Rudan, Igor Deary, Ian J. Karrasch, Stefan Probst-Hensch, Nicole M. Heinrich, Joachim Stubbe, Beate Wilson, James F. Wareham, Nicholas J. James, Alan L. Morris, Andrew P. Jarvelin, Marjo-Riitta Hayward, Caroline Sayers, Ian Strachan, David P. Hall, Ian P. Tobin, Martin D. |
| author_sort | Artigas, María Soler |
| collection | PubMed |
| description | Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC) and FEV(1)/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(−8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered. |
| format | Online Article Text |
| id | pubmed-4686825 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-46868252016-01-07 Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation Artigas, María Soler Wain, Louise V. Miller, Suzanne Kheirallah, Abdul Kader Huffman, Jennifer E. Ntalla, Ioanna Shrine, Nick Obeidat, Ma'en Trochet, Holly McArdle, Wendy L. Alves, Alexessander Couto Hui, Jennie Zhao, Jing Hua Joshi, Peter K. Teumer, Alexander Albrecht, Eva Imboden, Medea Rawal, Rajesh Lopez, Lorna M. Marten, Jonathan Enroth, Stefan Surakka, Ida Polasek, Ozren Lyytikäinen, Leo-Pekka Granell, Raquel Hysi, Pirro G. Flexeder, Claudia Mahajan, Anubha Beilby, John Bossé, Yohan Brandsma, Corry-Anke Campbell, Harry Gieger, Christian Gläser, Sven González, Juan R. Grallert, Harald Hammond, Chris J. Harris, Sarah E. Hartikainen, Anna-Liisa Heliövaara, Markku Henderson, John Hocking, Lynne Horikoshi, Momoko Hutri-Kähönen, Nina Ingelsson, Erik Johansson, Åsa Kemp, John P. Kolcic, Ivana Kumar, Ashish Lind, Lars Melén, Erik Musk, Arthur W. Navarro, Pau Nickle, David C. Padmanabhan, Sandosh Raitakari, Olli T. Ried, Janina S. Ripatti, Samuli Schulz, Holger Scott, Robert A. Sin, Don D. Starr, John M. Viñuela, Ana Völzke, Henry Wild, Sarah H. Wright, Alan F. Zemunik, Tatijana Jarvis, Deborah L. Spector, Tim D. Evans, David M. Lehtimäki, Terho Vitart, Veronique Kähönen, Mika Gyllensten, Ulf Rudan, Igor Deary, Ian J. Karrasch, Stefan Probst-Hensch, Nicole M. Heinrich, Joachim Stubbe, Beate Wilson, James F. Wareham, Nicholas J. James, Alan L. Morris, Andrew P. Jarvelin, Marjo-Riitta Hayward, Caroline Sayers, Ian Strachan, David P. Hall, Ian P. Tobin, Martin D. Nat Commun Article Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC) and FEV(1)/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(−8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered. Nature Publishing Group 2015-12-04 /pmc/articles/PMC4686825/ /pubmed/26635082 http://dx.doi.org/10.1038/ncomms9658 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Artigas, María Soler Wain, Louise V. Miller, Suzanne Kheirallah, Abdul Kader Huffman, Jennifer E. Ntalla, Ioanna Shrine, Nick Obeidat, Ma'en Trochet, Holly McArdle, Wendy L. Alves, Alexessander Couto Hui, Jennie Zhao, Jing Hua Joshi, Peter K. Teumer, Alexander Albrecht, Eva Imboden, Medea Rawal, Rajesh Lopez, Lorna M. Marten, Jonathan Enroth, Stefan Surakka, Ida Polasek, Ozren Lyytikäinen, Leo-Pekka Granell, Raquel Hysi, Pirro G. Flexeder, Claudia Mahajan, Anubha Beilby, John Bossé, Yohan Brandsma, Corry-Anke Campbell, Harry Gieger, Christian Gläser, Sven González, Juan R. Grallert, Harald Hammond, Chris J. Harris, Sarah E. Hartikainen, Anna-Liisa Heliövaara, Markku Henderson, John Hocking, Lynne Horikoshi, Momoko Hutri-Kähönen, Nina Ingelsson, Erik Johansson, Åsa Kemp, John P. Kolcic, Ivana Kumar, Ashish Lind, Lars Melén, Erik Musk, Arthur W. Navarro, Pau Nickle, David C. Padmanabhan, Sandosh Raitakari, Olli T. Ried, Janina S. Ripatti, Samuli Schulz, Holger Scott, Robert A. Sin, Don D. Starr, John M. Viñuela, Ana Völzke, Henry Wild, Sarah H. Wright, Alan F. Zemunik, Tatijana Jarvis, Deborah L. Spector, Tim D. Evans, David M. Lehtimäki, Terho Vitart, Veronique Kähönen, Mika Gyllensten, Ulf Rudan, Igor Deary, Ian J. Karrasch, Stefan Probst-Hensch, Nicole M. Heinrich, Joachim Stubbe, Beate Wilson, James F. Wareham, Nicholas J. James, Alan L. Morris, Andrew P. Jarvelin, Marjo-Riitta Hayward, Caroline Sayers, Ian Strachan, David P. Hall, Ian P. Tobin, Martin D. Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation |
| title | Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation |
| title_full | Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation |
| title_fullStr | Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation |
| title_full_unstemmed | Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation |
| title_short | Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation |
| title_sort | sixteen new lung function signals identified through 1000 genomes project reference panel imputation |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686825/ https://www.ncbi.nlm.nih.gov/pubmed/26635082 http://dx.doi.org/10.1038/ncomms9658 |
| work_keys_str_mv | AT artigasmariasoler sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT wainlouisev sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT millersuzanne sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT kheirallahabdulkader sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT huffmanjennifere sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT ntallaioanna sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT shrinenick sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT obeidatmaen sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT trochetholly sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT mcardlewendyl sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT alvesalexessandercouto sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT huijennie sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT zhaojinghua sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT joshipeterk sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT teumeralexander sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT albrechteva sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT imbodenmedea sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT rawalrajesh sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT lopezlornam sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT martenjonathan sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT enrothstefan sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT surakkaida sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT polasekozren sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT lyytikainenleopekka sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT granellraquel sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT hysipirrog sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT flexederclaudia sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT mahajananubha sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT beilbyjohn sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT bosseyohan sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT brandsmacorryanke sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT campbellharry sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT giegerchristian sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT glasersven sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT gonzalezjuanr sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT grallertharald sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT hammondchrisj sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT harrissarahe sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT hartikainenannaliisa sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT heliovaaramarkku sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT hendersonjohn sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT hockinglynne sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT horikoshimomoko sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT hutrikahonennina sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT ingelssonerik sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT johanssonasa sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT kempjohnp sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT kolcicivana sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT kumarashish sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT lindlars sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT melenerik sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT muskarthurw sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT navarropau sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT nickledavidc sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT padmanabhansandosh sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT raitakariollit sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT riedjaninas sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT ripattisamuli sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT schulzholger sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT scottroberta sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT sindond sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT starrjohnm sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT vinuelaana sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT volzkehenry sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT wildsarahh sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT wrightalanf sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT zemuniktatijana sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT jarvisdeborahl sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT spectortimd sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT evansdavidm sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT lehtimakiterho sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT vitartveronique sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT kahonenmika sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT gyllenstenulf sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT rudanigor sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT dearyianj sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT karraschstefan sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT probsthenschnicolem sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT heinrichjoachim sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT stubbebeate sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT wilsonjamesf sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT warehamnicholasj sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT jamesalanl sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT morrisandrewp sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT jarvelinmarjoriitta sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT haywardcaroline sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT sayersian sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT strachandavidp sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT hallianp sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation AT tobinmartind sixteennewlungfunctionsignalsidentifiedthrough1000genomesprojectreferencepanelimputation |