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Structural insight into the mechanism of synergistic autoinhibition of SAD kinases
The SAD/BRSK kinases participate in various important life processes, including neural development, cell cycle and energy metabolism. Like other members of the AMPK family, SAD contains an N-terminal kinase domain followed by the characteristic UBA and KA1 domains. Here we identify a unique autoinhi...
Autores principales: | Wu, Jing-Xiang, Cheng, Yun-Sheng, Wang, Jue, Chen, Lei, Ding, Mei, Wu, Jia-Wei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686854/ https://www.ncbi.nlm.nih.gov/pubmed/26626945 http://dx.doi.org/10.1038/ncomms9953 |
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