Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Na(v)1.7

Loss-of-function mutations in the SCN9A gene encoding voltage-gated sodium channel Na(v)1.7 cause congenital insensitivity to pain in humans and mice. Surprisingly, many potent selective antagonists of Na(v)1.7 are weak analgesics. We investigated whether Na(v)1.7, as well as contributing to electri...

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Detalles Bibliográficos
Autores principales: Minett, Michael S., Pereira, Vanessa, Sikandar, Shafaq, Matsuyama, Ayako, Lolignier, Stéphane, Kanellopoulos, Alexandros H., Mancini, Flavia, Iannetti, Gian D., Bogdanov, Yury D., Santana-Varela, Sonia, Millet, Queensta, Baskozos, Giorgios, MacAllister, Raymond, Cox, James J., Zhao, Jing, Wood, John N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686868/
https://www.ncbi.nlm.nih.gov/pubmed/26634308
http://dx.doi.org/10.1038/ncomms9967

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