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Architecture of high-affinity unnatural-base DNA aptamers toward pharmaceutical applications

We present a remodeling method for high-affinity unnatural-base DNA aptamers to augment their thermal stability and nuclease resistance, for use as drug candidates targeting specific proteins. Introducing a unique mini-hairpin DNA provides robust stability to unnatural-base DNA aptamers generated by...

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Detalles Bibliográficos
Autores principales:	Matsunaga, Ken-ichiro, Kimoto, Michiko, Hanson, Charlotte, Sanford, Michael, Young, Howard A., Hirao, Ichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686876/ https://www.ncbi.nlm.nih.gov/pubmed/26690672 http://dx.doi.org/10.1038/srep18478

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