An engineered scorpion toxin analogue with improved Kv1.3 selectivity displays reduced conformational flexibility

The voltage-gated Kv1.3 K(+) channel plays a key role in the activation of T lymphocytes. Kv1.3 blockers selectively suppress immune responses mediated by effector memory T cells, which indicates the great potential of selective Kv1.3 inhibitors in the therapy of certain autoimmune diseases. Anuroct...

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Detalles Bibliográficos
Autores principales: Bartok, Adam, Fehér, Krisztina, Bodor, Andrea, Rákosi, Kinga, Tóth, Gábor K., Kövér, Katalin E., Panyi, Gyorgy, Varga, Zoltan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686915/
https://www.ncbi.nlm.nih.gov/pubmed/26689143
http://dx.doi.org/10.1038/srep18397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686915/
https://www.ncbi.nlm.nih.gov/pubmed/26689143
http://dx.doi.org/10.1038/srep18397

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