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Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium

The International Knockout Mouse Consortium (IKMC) introduces its targeted constructs into C57BL/6N embryonic stem cells. However, breeding with a Cre-recombinase and/or Flp-recombinase mouse is required for the generation of a null allele with the IKMC cassette. Many recombinase strains are in the...

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Detalles Bibliográficos
Autores principales:	Fontaine, Danielle A., Davis, Dawn Belt
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2016
Materias:	Methodology Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686949/ https://www.ncbi.nlm.nih.gov/pubmed/26696638 http://dx.doi.org/10.2337/db15-0982

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