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Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus

Diabetes (DM) is prevalent in cirrhosis and may modulate the risk of hospitalization through gut dysbiosis. We aimed to define the role of gut microbiota on 90-day hospitalizations and of concomitant DM on microbiota. Cirrhotic outpatients with/without DM underwent stool and sigmoid mucosal microbia...

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Autores principales: Bajaj, Jasmohan S., Betrapally, Naga S., Hylemon, Phillip B., Thacker, Leroy R., Daita, Kalyani, Kang, Dae Joong, White, Melanie B., Unser, Ariel B., Fagan, Andrew, Gavis, Edith A., Sikaroodi, Masoumeh, Dalmet, Swati, Heuman, Douglas M., Gillevet, Patrick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686976/
https://www.ncbi.nlm.nih.gov/pubmed/26692421
http://dx.doi.org/10.1038/srep18559
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author Bajaj, Jasmohan S.
Betrapally, Naga S.
Hylemon, Phillip B.
Thacker, Leroy R.
Daita, Kalyani
Kang, Dae Joong
White, Melanie B.
Unser, Ariel B.
Fagan, Andrew
Gavis, Edith A.
Sikaroodi, Masoumeh
Dalmet, Swati
Heuman, Douglas M.
Gillevet, Patrick M.
author_facet Bajaj, Jasmohan S.
Betrapally, Naga S.
Hylemon, Phillip B.
Thacker, Leroy R.
Daita, Kalyani
Kang, Dae Joong
White, Melanie B.
Unser, Ariel B.
Fagan, Andrew
Gavis, Edith A.
Sikaroodi, Masoumeh
Dalmet, Swati
Heuman, Douglas M.
Gillevet, Patrick M.
author_sort Bajaj, Jasmohan S.
collection PubMed
description Diabetes (DM) is prevalent in cirrhosis and may modulate the risk of hospitalization through gut dysbiosis. We aimed to define the role of gut microbiota on 90-day hospitalizations and of concomitant DM on microbiota. Cirrhotic outpatients with/without DM underwent stool and sigmoid mucosal microbial analysis and were followed for 90 days. Microbial composition was compared between those with/without DM, and those who were hospitalized/not. Regression/ROC analyses for hospitalizations were performed using clinical and microbial features. 278 cirrhotics [39% hepatic encephalopathy (HE), 31%DM] underwent stool while 72 underwent mucosal analyses. Ultimately, 94 were hospitalized and they had higher MELD, proton pump inhibitor (PPI) use and HE without difference in DM. Stool/mucosal microbiota were significantly altered in those who were hospitalized (UNIFRAC p< = 1.0e-02). Specifically, lower stool Bacteroidaceae, Clostridiales XIV, Lachnospiraceae, Ruminococcacae and higher Enterococcaceae and Enterobacteriaceae were seen in hospitalized patients. Concomitant DM impacted microbiota UNIFRAC (stool, p = 0.003, mucosa,p = 0.04) with higher stool Bacteroidaceae and lower Ruminococcaeae. Stool Bacteroidaceaeae and Clostridiales XIV predicted 90-day hospitalizations independent of clinical predictors (MELD, HE, PPI). Stool and colonic mucosal microbiome are altered in cirrhotics who get hospitalized with independent prediction using stool Bacteroidaceae and Clostridiales XIV. Concomitant DM distinctly impacts gut microbiota without affecting hospitalizations.
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spelling pubmed-46869762015-12-31 Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus Bajaj, Jasmohan S. Betrapally, Naga S. Hylemon, Phillip B. Thacker, Leroy R. Daita, Kalyani Kang, Dae Joong White, Melanie B. Unser, Ariel B. Fagan, Andrew Gavis, Edith A. Sikaroodi, Masoumeh Dalmet, Swati Heuman, Douglas M. Gillevet, Patrick M. Sci Rep Article Diabetes (DM) is prevalent in cirrhosis and may modulate the risk of hospitalization through gut dysbiosis. We aimed to define the role of gut microbiota on 90-day hospitalizations and of concomitant DM on microbiota. Cirrhotic outpatients with/without DM underwent stool and sigmoid mucosal microbial analysis and were followed for 90 days. Microbial composition was compared between those with/without DM, and those who were hospitalized/not. Regression/ROC analyses for hospitalizations were performed using clinical and microbial features. 278 cirrhotics [39% hepatic encephalopathy (HE), 31%DM] underwent stool while 72 underwent mucosal analyses. Ultimately, 94 were hospitalized and they had higher MELD, proton pump inhibitor (PPI) use and HE without difference in DM. Stool/mucosal microbiota were significantly altered in those who were hospitalized (UNIFRAC p< = 1.0e-02). Specifically, lower stool Bacteroidaceae, Clostridiales XIV, Lachnospiraceae, Ruminococcacae and higher Enterococcaceae and Enterobacteriaceae were seen in hospitalized patients. Concomitant DM impacted microbiota UNIFRAC (stool, p = 0.003, mucosa,p = 0.04) with higher stool Bacteroidaceae and lower Ruminococcaeae. Stool Bacteroidaceaeae and Clostridiales XIV predicted 90-day hospitalizations independent of clinical predictors (MELD, HE, PPI). Stool and colonic mucosal microbiome are altered in cirrhotics who get hospitalized with independent prediction using stool Bacteroidaceae and Clostridiales XIV. Concomitant DM distinctly impacts gut microbiota without affecting hospitalizations. Nature Publishing Group 2015-12-22 /pmc/articles/PMC4686976/ /pubmed/26692421 http://dx.doi.org/10.1038/srep18559 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Bajaj, Jasmohan S.
Betrapally, Naga S.
Hylemon, Phillip B.
Thacker, Leroy R.
Daita, Kalyani
Kang, Dae Joong
White, Melanie B.
Unser, Ariel B.
Fagan, Andrew
Gavis, Edith A.
Sikaroodi, Masoumeh
Dalmet, Swati
Heuman, Douglas M.
Gillevet, Patrick M.
Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus
title Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus
title_full Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus
title_fullStr Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus
title_full_unstemmed Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus
title_short Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus
title_sort gut microbiota alterations can predict hospitalizations in cirrhosis independent of diabetes mellitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686976/
https://www.ncbi.nlm.nih.gov/pubmed/26692421
http://dx.doi.org/10.1038/srep18559
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