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Directly interrogating single quantum dot labelled UvrA(2) molecules on DNA tightropes using an optically trapped nanoprobe

In this study we describe a new methodology to physically probe individual complexes formed between proteins and DNA. By combining nanoscale, high speed physical force measurement with sensitive fluorescence imaging we investigate the complex formed between the prokaryotic DNA repair protein UvrA(2)...

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Detalles Bibliográficos
Autores principales:	Simons, Michelle, Pollard, Mark R., Hughes, Craig D., Ward, Andrew D., Van Houten, Bennett, Towrie, Mike, Botchway, Stan W., Parker, Anthony W., Kad, Neil M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686980/ https://www.ncbi.nlm.nih.gov/pubmed/26691010 http://dx.doi.org/10.1038/srep18486

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