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HIV-1 Protease Dimerization Dynamics Reveals a Transient Druggable Binding Pocket at the Interface

The binding mechanism of HIV-1 protease monomers leading to the catalytically competent dimeric enzyme has been investigated by means of state-of-the-art atomistic simulations. The emerging picture allows a deeper understanding of experimental observations and reveals that water molecules trapped at...

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Detalles Bibliográficos
Autores principales:	Pietrucci, Fabio, Vargiu, Attilio Vittorio, Kranjc, Agata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686983/ https://www.ncbi.nlm.nih.gov/pubmed/26692118 http://dx.doi.org/10.1038/srep18555

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