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Molecular Characterization of Subtype H11N9 Avian Influenza Virus Isolated from Shorebirds in Brazil

Migratory aquatic birds play an important role in the maintenance and spread of avian influenza viruses (AIV). Many species of aquatic migratory birds tend to use similar migration routes, also known as flyways, which serve as important circuits for the dissemination of AIV. In recent years there ha...

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Autores principales: Hurtado, Renata, Fabrizio, Thomas, Vanstreels, Ralph Eric Thijl, Krauss, Scott, Webby, Richard J., Webster, Robert G., Durigon, Edison Luiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687026/
https://www.ncbi.nlm.nih.gov/pubmed/26689791
http://dx.doi.org/10.1371/journal.pone.0145627
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author Hurtado, Renata
Fabrizio, Thomas
Vanstreels, Ralph Eric Thijl
Krauss, Scott
Webby, Richard J.
Webster, Robert G.
Durigon, Edison Luiz
author_facet Hurtado, Renata
Fabrizio, Thomas
Vanstreels, Ralph Eric Thijl
Krauss, Scott
Webby, Richard J.
Webster, Robert G.
Durigon, Edison Luiz
author_sort Hurtado, Renata
collection PubMed
description Migratory aquatic birds play an important role in the maintenance and spread of avian influenza viruses (AIV). Many species of aquatic migratory birds tend to use similar migration routes, also known as flyways, which serve as important circuits for the dissemination of AIV. In recent years there has been extensive surveillance of the virus in aquatic birds in the Northern Hemisphere; however in contrast only a few studies have been attempted to detect AIV in wild birds in South America. There are major flyways connecting South America to Central and North America, whereas avian migration routes between South America and the remaining continents are uncommon. As a result, it has been hypothesized that South American AIV strains would be most closely related to the strains from North America than to those from other regions in the world. We characterized the full genome of three AIV subtype H11N9 isolates obtained from ruddy turnstones (Arenaria interpres) on the Amazon coast of Brazil. For all gene segments, all three strains consistently clustered together within evolutionary lineages of AIV that had been previously described from aquatic birds in North America. In particular, the H11N9 isolates were remarkably closely related to AIV strains from shorebirds sampled at the Delaware Bay region, on the Northeastern coast of the USA, more than 5000 km away from where the isolates were retrieved. Additionally, there was also evidence of genetic similarity to AIV strains from ducks and teals from interior USA and Canada. These findings corroborate that migratory flyways of aquatic birds play an important role in determining the genetic structure of AIV in the Western hemisphere, with a strong epidemiological connectivity between North and South America.
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spelling pubmed-46870262016-01-07 Molecular Characterization of Subtype H11N9 Avian Influenza Virus Isolated from Shorebirds in Brazil Hurtado, Renata Fabrizio, Thomas Vanstreels, Ralph Eric Thijl Krauss, Scott Webby, Richard J. Webster, Robert G. Durigon, Edison Luiz PLoS One Research Article Migratory aquatic birds play an important role in the maintenance and spread of avian influenza viruses (AIV). Many species of aquatic migratory birds tend to use similar migration routes, also known as flyways, which serve as important circuits for the dissemination of AIV. In recent years there has been extensive surveillance of the virus in aquatic birds in the Northern Hemisphere; however in contrast only a few studies have been attempted to detect AIV in wild birds in South America. There are major flyways connecting South America to Central and North America, whereas avian migration routes between South America and the remaining continents are uncommon. As a result, it has been hypothesized that South American AIV strains would be most closely related to the strains from North America than to those from other regions in the world. We characterized the full genome of three AIV subtype H11N9 isolates obtained from ruddy turnstones (Arenaria interpres) on the Amazon coast of Brazil. For all gene segments, all three strains consistently clustered together within evolutionary lineages of AIV that had been previously described from aquatic birds in North America. In particular, the H11N9 isolates were remarkably closely related to AIV strains from shorebirds sampled at the Delaware Bay region, on the Northeastern coast of the USA, more than 5000 km away from where the isolates were retrieved. Additionally, there was also evidence of genetic similarity to AIV strains from ducks and teals from interior USA and Canada. These findings corroborate that migratory flyways of aquatic birds play an important role in determining the genetic structure of AIV in the Western hemisphere, with a strong epidemiological connectivity between North and South America. Public Library of Science 2015-12-21 /pmc/articles/PMC4687026/ /pubmed/26689791 http://dx.doi.org/10.1371/journal.pone.0145627 Text en © 2015 Hurtado et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hurtado, Renata
Fabrizio, Thomas
Vanstreels, Ralph Eric Thijl
Krauss, Scott
Webby, Richard J.
Webster, Robert G.
Durigon, Edison Luiz
Molecular Characterization of Subtype H11N9 Avian Influenza Virus Isolated from Shorebirds in Brazil
title Molecular Characterization of Subtype H11N9 Avian Influenza Virus Isolated from Shorebirds in Brazil
title_full Molecular Characterization of Subtype H11N9 Avian Influenza Virus Isolated from Shorebirds in Brazil
title_fullStr Molecular Characterization of Subtype H11N9 Avian Influenza Virus Isolated from Shorebirds in Brazil
title_full_unstemmed Molecular Characterization of Subtype H11N9 Avian Influenza Virus Isolated from Shorebirds in Brazil
title_short Molecular Characterization of Subtype H11N9 Avian Influenza Virus Isolated from Shorebirds in Brazil
title_sort molecular characterization of subtype h11n9 avian influenza virus isolated from shorebirds in brazil
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687026/
https://www.ncbi.nlm.nih.gov/pubmed/26689791
http://dx.doi.org/10.1371/journal.pone.0145627
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