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The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

NIH-12848 (NCGC00012848-02), a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor, was explored as a tool for investigating this enigmatic, low activity, lipid kinase. PI5P4K assays in vitro showed that NIH-12848 inhibited PI5P4Kγ with an IC(50) of approximately 1 μM but did no...

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Detalles Bibliográficos
Autores principales:	Clarke, Jonathan H., Giudici, Maria-Luisa, Burke, John E., Williams, Roger L., Maloney, David J., Marugan, Juan, Irvine, Robin F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687057/ https://www.ncbi.nlm.nih.gov/pubmed/25495341 http://dx.doi.org/10.1042/BJ20141333

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