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The Role of the Carboxyl Terminus Helix C-D Linker in Regulating KCNQ3 K(+) Current Amplitudes by Controlling Channel Trafficking
In the central and peripheral nervous system, the assembly of KCNQ3 with KCNQ2 as mostly heteromers, but also homomers, underlies “M-type” currents, a slowly-activating voltage-gated K(+) current that plays a dominant role in neuronal excitability. KCNQ3 homomers yield much smaller currents compared...
Autores principales: | Choveau, Frank S., Zhang, Jie, Bierbower, Sonya M., Sharma, Ramaswamy, Shapiro, Mark S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687061/ https://www.ncbi.nlm.nih.gov/pubmed/26692086 http://dx.doi.org/10.1371/journal.pone.0145367 |
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