Cargando…
The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British men
BACKGROUND: Current research has established obesity as one of the main modifiable risk factors for cognitive impairment. However, evidence on the relationships of total and regional body composition measures as well as sarcopenia with cognitive functioning in the older population remains inconsiste...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687114/ https://www.ncbi.nlm.nih.gov/pubmed/26692280 http://dx.doi.org/10.1186/s12877-015-0169-y |
_version_ | 1782406564880056320 |
---|---|
author | Papachristou, Efstathios Ramsay, Sheena E. Lennon, Lucy T. Papacosta, Olia Iliffe, Steve Whincup, Peter H. Wannamethee, S. Goya |
author_facet | Papachristou, Efstathios Ramsay, Sheena E. Lennon, Lucy T. Papacosta, Olia Iliffe, Steve Whincup, Peter H. Wannamethee, S. Goya |
author_sort | Papachristou, Efstathios |
collection | PubMed |
description | BACKGROUND: Current research has established obesity as one of the main modifiable risk factors for cognitive impairment. However, evidence on the relationships of total and regional body composition measures as well as sarcopenia with cognitive functioning in the older population remains inconsistent. METHODS: Data are based on 1,570 participants from the British Regional Heart Study (BRHS), a cohort of older British men from 24 British towns initiated in 1978–80, who were re-examined in 2010–12, aged 71–92 years. Cognitive functioning was assessed with the Test-Your-Memory cognitive screening tool. Body composition characteristics assessed using bioelectrical impedance analysis included total fat mass (FM), central FM, peripheral FM, and visceral fat level. Sarcopenia was defined using the European Working Group on Sarcopenia in Older People (EWGSOP) definition of severe sarcopenia and the Foundation for the National Institutes of Health (FNIH) sarcopenia project criteria. RESULTS: Among 1,570 men, 636 (41 %) were classified in the mild cognitive impairment (MCI) and 133 (8 %) in the severe cognitive impairment (SCI) groups. Age-adjusted multinomial logistic regressions showed that compared with participants in the normal cognitive ageing group, those with SCI were more likely to have waist circumference >102 cm, BMI >30 kg/m(2), to be in the upper quintile of total FM, central FM, peripheral FM and visceral fat level and to be sarcopenic. The relationships remained significant for total FM (RR = 2.16, 95 % CI 1.29–3.63), central FM (RR = 1.85, 95 % CI 1.09–3.14), peripheral FM (RR = 2.67, 95 % CI 1.59–4.48), visceral fat level (RR = 2.28, 95 % CI 1.32–3.94), BMI (RR = 2.25, 95 % CI 1.36–3.72) and waist circumference (RR = 1.63, 95 % CI 1.05–2.55) after adjustments for alcohol, smoking, social class, physical activity and history of cardiovascular diseases or diabetes. After further adjustments for interleukin-6 and insulin resistance, central FM, waist circumference and sarcopenia were no longer significantly associated with SCI. CONCLUSIONS: Increased levels of peripheral FM, visceral fat level, and BMI are associated with SCI among older people. Distinct pathophysiological mechanisms link regional adipose tissue deposition and cognitive functioning. |
format | Online Article Text |
id | pubmed-4687114 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-46871142015-12-23 The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British men Papachristou, Efstathios Ramsay, Sheena E. Lennon, Lucy T. Papacosta, Olia Iliffe, Steve Whincup, Peter H. Wannamethee, S. Goya BMC Geriatr Research Article BACKGROUND: Current research has established obesity as one of the main modifiable risk factors for cognitive impairment. However, evidence on the relationships of total and regional body composition measures as well as sarcopenia with cognitive functioning in the older population remains inconsistent. METHODS: Data are based on 1,570 participants from the British Regional Heart Study (BRHS), a cohort of older British men from 24 British towns initiated in 1978–80, who were re-examined in 2010–12, aged 71–92 years. Cognitive functioning was assessed with the Test-Your-Memory cognitive screening tool. Body composition characteristics assessed using bioelectrical impedance analysis included total fat mass (FM), central FM, peripheral FM, and visceral fat level. Sarcopenia was defined using the European Working Group on Sarcopenia in Older People (EWGSOP) definition of severe sarcopenia and the Foundation for the National Institutes of Health (FNIH) sarcopenia project criteria. RESULTS: Among 1,570 men, 636 (41 %) were classified in the mild cognitive impairment (MCI) and 133 (8 %) in the severe cognitive impairment (SCI) groups. Age-adjusted multinomial logistic regressions showed that compared with participants in the normal cognitive ageing group, those with SCI were more likely to have waist circumference >102 cm, BMI >30 kg/m(2), to be in the upper quintile of total FM, central FM, peripheral FM and visceral fat level and to be sarcopenic. The relationships remained significant for total FM (RR = 2.16, 95 % CI 1.29–3.63), central FM (RR = 1.85, 95 % CI 1.09–3.14), peripheral FM (RR = 2.67, 95 % CI 1.59–4.48), visceral fat level (RR = 2.28, 95 % CI 1.32–3.94), BMI (RR = 2.25, 95 % CI 1.36–3.72) and waist circumference (RR = 1.63, 95 % CI 1.05–2.55) after adjustments for alcohol, smoking, social class, physical activity and history of cardiovascular diseases or diabetes. After further adjustments for interleukin-6 and insulin resistance, central FM, waist circumference and sarcopenia were no longer significantly associated with SCI. CONCLUSIONS: Increased levels of peripheral FM, visceral fat level, and BMI are associated with SCI among older people. Distinct pathophysiological mechanisms link regional adipose tissue deposition and cognitive functioning. BioMed Central 2015-12-21 /pmc/articles/PMC4687114/ /pubmed/26692280 http://dx.doi.org/10.1186/s12877-015-0169-y Text en © Papachristou et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Papachristou, Efstathios Ramsay, Sheena E. Lennon, Lucy T. Papacosta, Olia Iliffe, Steve Whincup, Peter H. Wannamethee, S. Goya The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British men |
title | The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British men |
title_full | The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British men |
title_fullStr | The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British men |
title_full_unstemmed | The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British men |
title_short | The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British men |
title_sort | relationships between body composition characteristics and cognitive functioning in a population-based sample of older british men |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687114/ https://www.ncbi.nlm.nih.gov/pubmed/26692280 http://dx.doi.org/10.1186/s12877-015-0169-y |
work_keys_str_mv | AT papachristouefstathios therelationshipsbetweenbodycompositioncharacteristicsandcognitivefunctioninginapopulationbasedsampleofolderbritishmen AT ramsaysheenae therelationshipsbetweenbodycompositioncharacteristicsandcognitivefunctioninginapopulationbasedsampleofolderbritishmen AT lennonlucyt therelationshipsbetweenbodycompositioncharacteristicsandcognitivefunctioninginapopulationbasedsampleofolderbritishmen AT papacostaolia therelationshipsbetweenbodycompositioncharacteristicsandcognitivefunctioninginapopulationbasedsampleofolderbritishmen AT iliffesteve therelationshipsbetweenbodycompositioncharacteristicsandcognitivefunctioninginapopulationbasedsampleofolderbritishmen AT whincuppeterh therelationshipsbetweenbodycompositioncharacteristicsandcognitivefunctioninginapopulationbasedsampleofolderbritishmen AT wannametheesgoya therelationshipsbetweenbodycompositioncharacteristicsandcognitivefunctioninginapopulationbasedsampleofolderbritishmen AT papachristouefstathios relationshipsbetweenbodycompositioncharacteristicsandcognitivefunctioninginapopulationbasedsampleofolderbritishmen AT ramsaysheenae relationshipsbetweenbodycompositioncharacteristicsandcognitivefunctioninginapopulationbasedsampleofolderbritishmen AT lennonlucyt relationshipsbetweenbodycompositioncharacteristicsandcognitivefunctioninginapopulationbasedsampleofolderbritishmen AT papacostaolia relationshipsbetweenbodycompositioncharacteristicsandcognitivefunctioninginapopulationbasedsampleofolderbritishmen AT iliffesteve relationshipsbetweenbodycompositioncharacteristicsandcognitivefunctioninginapopulationbasedsampleofolderbritishmen AT whincuppeterh relationshipsbetweenbodycompositioncharacteristicsandcognitivefunctioninginapopulationbasedsampleofolderbritishmen AT wannametheesgoya relationshipsbetweenbodycompositioncharacteristicsandcognitivefunctioninginapopulationbasedsampleofolderbritishmen |