Non-coding yet non-trivial: a review on the computational genomics of lincRNAs

Long intergenic non-coding RNAs (lincRNAs) represent one of the most mysterious RNA species encoded by the human genome. Thanks to next generation sequencing (NGS) technology and its applications, we have recently witnessed a surge in non-coding RNA research, including lincRNA research. Here, we sum...

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Detalles Bibliográficos
Autores principales: Ching, Travers, Masaki, Jayson, Weirather, Jason, Garmire, Lana X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687140/
https://www.ncbi.nlm.nih.gov/pubmed/26697116
http://dx.doi.org/10.1186/s13040-015-0075-z
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author Ching, Travers
Masaki, Jayson
Weirather, Jason
Garmire, Lana X.
author_facet Ching, Travers
Masaki, Jayson
Weirather, Jason
Garmire, Lana X.
author_sort Ching, Travers
collection PubMed
description Long intergenic non-coding RNAs (lincRNAs) represent one of the most mysterious RNA species encoded by the human genome. Thanks to next generation sequencing (NGS) technology and its applications, we have recently witnessed a surge in non-coding RNA research, including lincRNA research. Here, we summarize the recent advancement in genomics studies of lincRNAs. We review the emerging characteristics of lincRNAs, the experimental and computational approaches to identify lincRNAs, their known mechanisms of regulation, the computational methods and resources for lincRNA functional predictions, and discuss the challenges to understanding lincRNA comprehensively.
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spelling pubmed-46871402015-12-23 Non-coding yet non-trivial: a review on the computational genomics of lincRNAs Ching, Travers Masaki, Jayson Weirather, Jason Garmire, Lana X. BioData Min Review Long intergenic non-coding RNAs (lincRNAs) represent one of the most mysterious RNA species encoded by the human genome. Thanks to next generation sequencing (NGS) technology and its applications, we have recently witnessed a surge in non-coding RNA research, including lincRNA research. Here, we summarize the recent advancement in genomics studies of lincRNAs. We review the emerging characteristics of lincRNAs, the experimental and computational approaches to identify lincRNAs, their known mechanisms of regulation, the computational methods and resources for lincRNA functional predictions, and discuss the challenges to understanding lincRNA comprehensively. BioMed Central 2015-12-22 /pmc/articles/PMC4687140/ /pubmed/26697116 http://dx.doi.org/10.1186/s13040-015-0075-z Text en © Ching et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Ching, Travers
Masaki, Jayson
Weirather, Jason
Garmire, Lana X.
Non-coding yet non-trivial: a review on the computational genomics of lincRNAs
title Non-coding yet non-trivial: a review on the computational genomics of lincRNAs
title_full Non-coding yet non-trivial: a review on the computational genomics of lincRNAs
title_fullStr Non-coding yet non-trivial: a review on the computational genomics of lincRNAs
title_full_unstemmed Non-coding yet non-trivial: a review on the computational genomics of lincRNAs
title_short Non-coding yet non-trivial: a review on the computational genomics of lincRNAs
title_sort non-coding yet non-trivial: a review on the computational genomics of lincrnas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687140/
https://www.ncbi.nlm.nih.gov/pubmed/26697116
http://dx.doi.org/10.1186/s13040-015-0075-z
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