Oncolytic Newcastle disease virus expressing chimeric antibody enhanced anti-tumor efficacy in orthotopic hepatoma-bearing mice

BACKGROUND: Oncolytic virus which arms the therapeutic gene to enhance anti-tumor activity is a prevalent strategy to improve oncovirotherapy of cancer. Newcastle disease virus (NDV) is a naturally oncolytic virus used for cancer therapy. Previously, we generated a mouse-human chimeric HAb18 antibod...

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Detalles Bibliográficos
Autores principales: Wei, Ding, Li, Qian, Wang, Xi-Long, Wang, Yuan, Xu, Jing, Feng, Fei, Nan, Gang, Wang, Bin, Li, Can, Guo, Ting, Chen, Zhi-Nan, Bian, Huijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687166/
https://www.ncbi.nlm.nih.gov/pubmed/26689432
http://dx.doi.org/10.1186/s13046-015-0271-1

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