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Effect of aerobic exercise training on regional blood flow and vascular resistance in diabetic rats
BACKGROUND: Hyperglycemia has been associated with decreased blood flow in various organs, leading to tissue damage and dysfunctions. Exercise training (ET) is known to promote beneficial changes in the autonomic nervous system and may have effects on circulation. The aim of this study was to evalua...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687277/ https://www.ncbi.nlm.nih.gov/pubmed/26697119 http://dx.doi.org/10.1186/s13098-015-0109-1 |
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author | Freitas, Sarah Cristina Ferreira Harthmann, Ângela d’Avila Rodrigues, Bruno Irigoyen, Maria-Cláudia De Angelis, Kátia |
author_facet | Freitas, Sarah Cristina Ferreira Harthmann, Ângela d’Avila Rodrigues, Bruno Irigoyen, Maria-Cláudia De Angelis, Kátia |
author_sort | Freitas, Sarah Cristina Ferreira |
collection | PubMed |
description | BACKGROUND: Hyperglycemia has been associated with decreased blood flow in various organs, leading to tissue damage and dysfunctions. Exercise training (ET) is known to promote beneficial changes in the autonomic nervous system and may have effects on circulation. The aim of this study was to evaluate coronary and renal blood flows and vascular resistances after ET in diabetic rats. METHODS: Thirty-two rats were divided into four groups (n = 8): sedentary control (SC), trained control (TC), sedentary diabetic (SD), trained diabetic (TD). Diabetes was induced by an injection of streptozotocin (STZ, 50 mg/kg). The ET was performed on a treadmill for 10 weeks. The blood flows were measured using colored microspheres. RESULTS: The diabetic groups presented hyperglycemia (blood glucose >350 mg/dL) and ET did not change this parameter. The SD group showed reduced renal blood flow when compared to SC group, and ET was able to normalize this parameter in TD rats (SC: 4.3 ± 0.5; TC: 2.9 ± 0.3; SD: 1.9 ± 0.4; TD: 3.2 ± 0.4 mL/min/g). TD group presented increased coronary blood flow in relation to SD group (SC: 2.3 ± 0.23; TC: 2.8 ± 0.5; SD: 1.2 ± 0.4; TD: 3.0 ± 0.4 mL/min/g). The heart and kidneys vascular resistance were increased in SD group when compared to SC group, and ET was able to reverse these changes. CONCLUSIONS: Given the relevance of cardiomyopathy and nephropathy in mortality of diabetics, our results demonstrated that ET is effective in improving coronary and renal blood flows and vascular resistances in STZ-diabetic rats, reinforcing the positive role of this approach in preventing hyperglycemia-induced long-term organ damage. |
format | Online Article Text |
id | pubmed-4687277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-46872772015-12-23 Effect of aerobic exercise training on regional blood flow and vascular resistance in diabetic rats Freitas, Sarah Cristina Ferreira Harthmann, Ângela d’Avila Rodrigues, Bruno Irigoyen, Maria-Cláudia De Angelis, Kátia Diabetol Metab Syndr Research BACKGROUND: Hyperglycemia has been associated with decreased blood flow in various organs, leading to tissue damage and dysfunctions. Exercise training (ET) is known to promote beneficial changes in the autonomic nervous system and may have effects on circulation. The aim of this study was to evaluate coronary and renal blood flows and vascular resistances after ET in diabetic rats. METHODS: Thirty-two rats were divided into four groups (n = 8): sedentary control (SC), trained control (TC), sedentary diabetic (SD), trained diabetic (TD). Diabetes was induced by an injection of streptozotocin (STZ, 50 mg/kg). The ET was performed on a treadmill for 10 weeks. The blood flows were measured using colored microspheres. RESULTS: The diabetic groups presented hyperglycemia (blood glucose >350 mg/dL) and ET did not change this parameter. The SD group showed reduced renal blood flow when compared to SC group, and ET was able to normalize this parameter in TD rats (SC: 4.3 ± 0.5; TC: 2.9 ± 0.3; SD: 1.9 ± 0.4; TD: 3.2 ± 0.4 mL/min/g). TD group presented increased coronary blood flow in relation to SD group (SC: 2.3 ± 0.23; TC: 2.8 ± 0.5; SD: 1.2 ± 0.4; TD: 3.0 ± 0.4 mL/min/g). The heart and kidneys vascular resistance were increased in SD group when compared to SC group, and ET was able to reverse these changes. CONCLUSIONS: Given the relevance of cardiomyopathy and nephropathy in mortality of diabetics, our results demonstrated that ET is effective in improving coronary and renal blood flows and vascular resistances in STZ-diabetic rats, reinforcing the positive role of this approach in preventing hyperglycemia-induced long-term organ damage. BioMed Central 2015-12-21 /pmc/articles/PMC4687277/ /pubmed/26697119 http://dx.doi.org/10.1186/s13098-015-0109-1 Text en © Freitas et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Freitas, Sarah Cristina Ferreira Harthmann, Ângela d’Avila Rodrigues, Bruno Irigoyen, Maria-Cláudia De Angelis, Kátia Effect of aerobic exercise training on regional blood flow and vascular resistance in diabetic rats |
title | Effect of aerobic exercise training on regional blood flow and vascular resistance in diabetic rats |
title_full | Effect of aerobic exercise training on regional blood flow and vascular resistance in diabetic rats |
title_fullStr | Effect of aerobic exercise training on regional blood flow and vascular resistance in diabetic rats |
title_full_unstemmed | Effect of aerobic exercise training on regional blood flow and vascular resistance in diabetic rats |
title_short | Effect of aerobic exercise training on regional blood flow and vascular resistance in diabetic rats |
title_sort | effect of aerobic exercise training on regional blood flow and vascular resistance in diabetic rats |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687277/ https://www.ncbi.nlm.nih.gov/pubmed/26697119 http://dx.doi.org/10.1186/s13098-015-0109-1 |
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