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Trends in HPV cervical and seroprevalence and associations between oral and genital infection and serum antibodies in NHANES 2003–2012

BACKGROUND: HPV infects multiple sites in the epithelium, including the genitals and oral cavity. The relation between genital and oral infections and serum antibodies can help explain the natural history and epidemiology of HPV. METHODS: We analyzed HPV data from NHANES derived from self-collected...

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Autores principales: Brouwer, Andrew F., Eisenberg, Marisa C., Carey, Thomas E., Meza, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687319/
https://www.ncbi.nlm.nih.gov/pubmed/26689203
http://dx.doi.org/10.1186/s12879-015-1314-0
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author Brouwer, Andrew F.
Eisenberg, Marisa C.
Carey, Thomas E.
Meza, Rafael
author_facet Brouwer, Andrew F.
Eisenberg, Marisa C.
Carey, Thomas E.
Meza, Rafael
author_sort Brouwer, Andrew F.
collection PubMed
description BACKGROUND: HPV infects multiple sites in the epithelium, including the genitals and oral cavity. The relation between genital and oral infections and serum antibodies can help explain the natural history and epidemiology of HPV. METHODS: We analyzed HPV data from NHANES derived from self-collected vaginal swabs (women ages 14–59, 2003–12), oral rinses (men and women 14–69, 2009–12), and serum (men and women 14-59, 2003–10). RESULTS: Type-concordance of cervicogenital and oral infections in women was found to vary widely by age. Prevalence of oral infections with type-concordant antibodies was low but varied by sex: 0.2 % (95 % CI 0.0–0.8) for women vs 0.8 % (95 % CI 0.4–1.3) for men. Vaccination was associated with a reduced risk of cervicogenital infection for vaccine genotypes among ages 14–17 (0.2 (95 % CI 0.1–0.8)) and 18–24 (0.2 (95 % CI 0.1–0.3). Seroprevalence trends in women showed a dramatic increase for recent birth cohorts, likely due to vaccination. By contrast, trends for men remained relatively constant. Age-specific cervicogenital prevalence showed a consistent peak in the late teens and twenties. Relative cervicogenital prevalence has largely been decreasing since the 1940–50 birth cohort. CONCLUSIONS: There are complex patterns in HPV prevalence trends and type-concordance across infection sites and serum antibodies. A multisite sampling scheme is needed to better understand the epidemiology and natural history of HPV. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-015-1314-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-46873192015-12-23 Trends in HPV cervical and seroprevalence and associations between oral and genital infection and serum antibodies in NHANES 2003–2012 Brouwer, Andrew F. Eisenberg, Marisa C. Carey, Thomas E. Meza, Rafael BMC Infect Dis Research Article BACKGROUND: HPV infects multiple sites in the epithelium, including the genitals and oral cavity. The relation between genital and oral infections and serum antibodies can help explain the natural history and epidemiology of HPV. METHODS: We analyzed HPV data from NHANES derived from self-collected vaginal swabs (women ages 14–59, 2003–12), oral rinses (men and women 14–69, 2009–12), and serum (men and women 14-59, 2003–10). RESULTS: Type-concordance of cervicogenital and oral infections in women was found to vary widely by age. Prevalence of oral infections with type-concordant antibodies was low but varied by sex: 0.2 % (95 % CI 0.0–0.8) for women vs 0.8 % (95 % CI 0.4–1.3) for men. Vaccination was associated with a reduced risk of cervicogenital infection for vaccine genotypes among ages 14–17 (0.2 (95 % CI 0.1–0.8)) and 18–24 (0.2 (95 % CI 0.1–0.3). Seroprevalence trends in women showed a dramatic increase for recent birth cohorts, likely due to vaccination. By contrast, trends for men remained relatively constant. Age-specific cervicogenital prevalence showed a consistent peak in the late teens and twenties. Relative cervicogenital prevalence has largely been decreasing since the 1940–50 birth cohort. CONCLUSIONS: There are complex patterns in HPV prevalence trends and type-concordance across infection sites and serum antibodies. A multisite sampling scheme is needed to better understand the epidemiology and natural history of HPV. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-015-1314-0) contains supplementary material, which is available to authorized users. BioMed Central 2015-12-21 /pmc/articles/PMC4687319/ /pubmed/26689203 http://dx.doi.org/10.1186/s12879-015-1314-0 Text en © Brouwer et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Brouwer, Andrew F.
Eisenberg, Marisa C.
Carey, Thomas E.
Meza, Rafael
Trends in HPV cervical and seroprevalence and associations between oral and genital infection and serum antibodies in NHANES 2003–2012
title Trends in HPV cervical and seroprevalence and associations between oral and genital infection and serum antibodies in NHANES 2003–2012
title_full Trends in HPV cervical and seroprevalence and associations between oral and genital infection and serum antibodies in NHANES 2003–2012
title_fullStr Trends in HPV cervical and seroprevalence and associations between oral and genital infection and serum antibodies in NHANES 2003–2012
title_full_unstemmed Trends in HPV cervical and seroprevalence and associations between oral and genital infection and serum antibodies in NHANES 2003–2012
title_short Trends in HPV cervical and seroprevalence and associations between oral and genital infection and serum antibodies in NHANES 2003–2012
title_sort trends in hpv cervical and seroprevalence and associations between oral and genital infection and serum antibodies in nhanes 2003–2012
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687319/
https://www.ncbi.nlm.nih.gov/pubmed/26689203
http://dx.doi.org/10.1186/s12879-015-1314-0
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