Cargando…

Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma

BACKGROUND: Abnormal activation of STAT3 and miR-21 plays a vital role in progression and invasion of solid tumors. The cyclin-dependent kinase 5 (CDK5) is reported to contribute to cancer metastasis by regulating epithelial-mesenchymal transition (EMT). However, the role of STAT3/miR-21 axis and CD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Shan-Shan, Zhou, Xuan, Huang, Yuan-Yuan, Kong, Ling-Ping, Mei, Mei, Guo, Wen-Yu, Zhao, Ming-Hui, Ren, Yu, Shen, Qiang, Zhang, Lun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687320/ https://www.ncbi.nlm.nih.gov/pubmed/26690371 http://dx.doi.org/10.1186/s12943-015-0487-x

Ejemplares similares

WP1066 Sensitizes Oral Squamous Cell Carcinoma Cells to Cisplatin by Targeting STAT3/miR-21 axis
por: Zhou, Xuan, et al.
Publicado: (2014)

CDK1 Promotes Epithelial–Mesenchymal Transition and Migration of Head and Neck Squamous Carcinoma Cells by Repressing ∆Np63α-Mediated Transcriptional Regulation
por: Chen, Huimin, et al.
Publicado: (2022)

Epithelial-to-Mesenchymal Transition-Derived Heterogeneity in Head and Neck Squamous Cell Carcinomas
por: Baumeister, Philipp, et al.
Publicado: (2021)

PLAU Promotes Cell Proliferation and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma
por: Chen, Guangjin, et al.
Publicado: (2021)

STAT3 regulates hypoxia-induced epithelial mesenchymal transition in oesophageal squamous cell cancer
por: CUI, YAO, et al.
Publicado: (2016)

CDK7 Predicts Worse Outcome in Head and Neck Squamous-Cell Cancer
por: Jagomast, Tobias, et al.
Publicado: (2022)

Nicotine Promotes Acquisition of Stem Cell and Epithelial-to-Mesenchymal Properties in Head and Neck Squamous Cell Carcinoma
por: Yu, Michael Andrew, et al.
Publicado: (2012)

Epithelial–Mesenchymal Transition Associated with Head and Neck Squamous Cell Carcinomas: A Review
por: González-González, Rogelio, et al.
Publicado: (2021)

CD133/Src Axis Mediates Tumor Initiating Property and Epithelial-Mesenchymal Transition of Head and Neck Cancer
por: Chen, Yu-Syuan, et al.
Publicado: (2011)

Long Non Coding RNA MALAT1 Promotes Tumor Growth and Metastasis by inducing Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma
por: Zhou, Xuan, et al.
Publicado: (2015)

CircRNA_ACAP2 Suppresses EMT in Head and Neck Squamous Cell Carcinoma by Targeting the miR-21-5p/STAT3 Signaling Axis
por: Ma, Chuan, et al.
Publicado: (2020)

Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis
por: Qin, Mengyao, et al.
Publicado: (2022)

Evidence for Epithelial-Mesenchymal Transition in Cancer Stem Cells of Head and Neck Squamous Cell Carcinoma
por: Chen, Chao, et al.
Publicado: (2011)

Markers of Epithelial to Mesenchymal Transition in Association with Survival in Head and Neck Squamous Cell Carcinoma (HNSCC)
por: Pectasides, Eirini, et al.
Publicado: (2014)

Multi-Omics Identification of Genetic Alterations in Head and Neck Squamous Cell Carcinoma and Therapeutic Efficacy of HNC018 as a Novel Multi-Target Agent for c-MET/STAT3/AKT Signaling Axis
por: Khedkar, Harshita Nivrutti, et al.
Publicado: (2023)

TEAD4 overexpression promotes epithelial-mesenchymal transition and associates with aggressiveness and adverse prognosis in head neck squamous cell carcinoma
por: Zhang, Wei, et al.
Publicado: (2018)

The Clinicopathological Significance of Epithelial Mesenchymal Transition Associated Protein Expression in Head and Neck Squamous Cell Carcinoma
por: Kim, Kyu Ho, et al.
Publicado: (2014)

DDB2 regulates Epithelial-to-Mesenchymal Transition (EMT) in Oral/Head and Neck Squamous Cell Carcinoma
por: Bommi, Prashant V., et al.
Publicado: (2018)

PD-L1 expression is associated with epithelial-mesenchymal transition in head and neck squamous cell carcinoma
por: Ock, Chan-Young, et al.
Publicado: (2016)

UBE2O Promotes Progression and Epithelial–Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma
por: Chen, Xiyu, et al.
Publicado: (2020)

Characterizing the epithelial–mesenchymal transition status of circulating tumor cells in head and neck squamous cell carcinoma
por: Payne, Karl, et al.
Publicado: (2022)

Epithelial-mesenchymal transition gene signature is associated with prognosis and tumor microenvironment in head and neck squamous cell carcinoma
por: Jung, Ah Ra, et al.
Publicado: (2020)

An Epithelial–Mesenchymal Transition Hallmark Gene-Based Risk Score System in Head and Neck Squamous-Cell Carcinoma
por: Liang, Feifei, et al.
Publicado: (2021)

Interferon-alpha promotes immunosuppression through IFNAR1/STAT1 signalling in head and neck squamous cell carcinoma
por: Ma, Hailong, et al.
Publicado: (2018)

Exosomes: Potential Biomarkers and Functions in Head and Neck Squamous Cell Carcinoma
por: Li, Ting, et al.
Publicado: (2022)

The translational significance of epithelial-mesenchymal transition in head and neck cancer
por: Graves, Christian A, et al.
Publicado: (2014)

Epithelial-to-Mesenchymal Transition in the Pathogenesis and Therapy of Head and Neck Cancer
por: Thierauf, Julia, et al.
Publicado: (2017)

Malignant and Nonmalignant Gene Signatures in Squamous Head and Neck Cancer
por: Worsham, Maria J., et al.
Publicado: (2012)

Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma
por: Bharadwaj, Uddalak, et al.
Publicado: (2016)

Corrigendum: Exosomes: Potential biomarkers and functions in head and neck squamous cell carcinoma
por: Li, Ting, et al.
Publicado: (2022)

Somatic Mutations and Genetic Variants of NOTCH1 in Head and Neck Squamous Cell Carcinoma Occurrence and Development
por: Liu, Yu-Fan, et al.
Publicado: (2016)

Overexpression of LIMA1 Indicates Poor Prognosis and Promotes Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma
por: Ma, Wei, et al.
Publicado: (2022)

Survival prognostic factors for metachronous second primary head and neck squamous cell carcinoma
por: Chen, Jin‐Hua, et al.
Publicado: (2016)

LINC00460 Promotes Cell Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition of Head and Neck Squamous Cell Carcinoma via miR-320a/BGN Axis
por: Yang, Yifan, et al.
Publicado: (2021)

MicroRNA-181a promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma via the TGF-β/Smad pathway
por: Xu, Run, et al.
Publicado: (2021)

Tumor associated macrophages induce epithelial to mesenchymal transition via the EGFR/ERK1/2 pathway in head and neck squamous cell carcinoma
por: Gao, Lu, et al.
Publicado: (2018)

Corrigendum: Somatic Mutations and Genetic Variants of NOTCH1 in Head and Neck Squamous Cell Carcinoma Occurrence and Development
por: Liu, Yu-Fan, et al.
Publicado: (2016)

A HPV16-related prognostic indicator for head and neck squamous cell carcinoma
por: Zhang, Qian, et al.
Publicado: (2020)

Downregulated lncRNA GAS5 and Upregulated miR-21 Lead to Epithelial–Mesenchymal Transition and Lung Metastasis of Osteosarcomas
por: Wang, Ying, et al.
Publicado: (2021)

Correction: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma
por: Bharadwaj, Uddalak, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0b5lq8ksfof49hl2g68rlo6h45