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Biocompatibility and magnetic resonance imaging characteristics of carbon nanotube yarn neural electrodes in a rat model
BACKGROUND: Implantation of deep brain stimulation (DBS) electrodes is a landmark therapy for movement disorders and some mental conditions. Compared to conventional platinum–iridium (Pt–Ir) electrodes, carbon nanotube yarns (CNTY) electrodes have improved stability and interface characteristics wit...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687330/ https://www.ncbi.nlm.nih.gov/pubmed/26689592 http://dx.doi.org/10.1186/s12938-015-0113-6 |
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author | Guo, Yi Duan, Wanru Ma, Chao Jiang, Changqing Xie, Yikuan Hao, Hongwei Wang, Renzhi Li, Luming |
author_facet | Guo, Yi Duan, Wanru Ma, Chao Jiang, Changqing Xie, Yikuan Hao, Hongwei Wang, Renzhi Li, Luming |
author_sort | Guo, Yi |
collection | PubMed |
description | BACKGROUND: Implantation of deep brain stimulation (DBS) electrodes is a landmark therapy for movement disorders and some mental conditions. Compared to conventional platinum–iridium (Pt–Ir) electrodes, carbon nanotube yarns (CNTY) electrodes have improved stability and interface characteristics with less distortion during high field strength MRI. Sprague–Dawley rat models were used to examine thein vivo histological and imaging properties of biocompatible CNTY throughout the subacute period. METHODS: Sprague–Dawley rats received CNTY (n = 16) or Pt–Ir control (n = 16) electrodes. Behavioral markers, body weight, and survival were recorded. Comparative histology (HE, NeuN, CD68, and GFAP) was performed at 1, 6, and 12 weeks post-implantation; 3.0T MRI was performed at 1 and 12 weeks. RESULTS: Of 32 rats, 30 (15 per group) survived implantation without reduced activity, paralysis, or incapacity to feed. Following implantation, progressive decreases in macrophage activation and neuron-depleted margins surrounding electrodes were observed in both groups. Inflammatory marker expression (CD68) was significantly lower in rats with implanted CNTY electrodes compared to controls at all time points. CNTY electrodes also caused less inflammation and shallower depths of macrophage penetration and neural disruption relative to the interface. Artifacts and distortion were observed on MRI of Pt–Ir but not CNTY electrodes. CONCLUSIONS: CNTY electrodes exhibited reduced inflammatory margins compared to Pt–Ir electrodes throughout the subacute period, indicating reduced initial trauma, better overall biocompatibility, and reduced fibrous tissue formation. Coupled with less MRI distortion, CNTY electrodes may be useful alternatives when there is a need to monitor electrode placement by MRI. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12938-015-0113-6) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4687330 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-46873302015-12-23 Biocompatibility and magnetic resonance imaging characteristics of carbon nanotube yarn neural electrodes in a rat model Guo, Yi Duan, Wanru Ma, Chao Jiang, Changqing Xie, Yikuan Hao, Hongwei Wang, Renzhi Li, Luming Biomed Eng Online Research BACKGROUND: Implantation of deep brain stimulation (DBS) electrodes is a landmark therapy for movement disorders and some mental conditions. Compared to conventional platinum–iridium (Pt–Ir) electrodes, carbon nanotube yarns (CNTY) electrodes have improved stability and interface characteristics with less distortion during high field strength MRI. Sprague–Dawley rat models were used to examine thein vivo histological and imaging properties of biocompatible CNTY throughout the subacute period. METHODS: Sprague–Dawley rats received CNTY (n = 16) or Pt–Ir control (n = 16) electrodes. Behavioral markers, body weight, and survival were recorded. Comparative histology (HE, NeuN, CD68, and GFAP) was performed at 1, 6, and 12 weeks post-implantation; 3.0T MRI was performed at 1 and 12 weeks. RESULTS: Of 32 rats, 30 (15 per group) survived implantation without reduced activity, paralysis, or incapacity to feed. Following implantation, progressive decreases in macrophage activation and neuron-depleted margins surrounding electrodes were observed in both groups. Inflammatory marker expression (CD68) was significantly lower in rats with implanted CNTY electrodes compared to controls at all time points. CNTY electrodes also caused less inflammation and shallower depths of macrophage penetration and neural disruption relative to the interface. Artifacts and distortion were observed on MRI of Pt–Ir but not CNTY electrodes. CONCLUSIONS: CNTY electrodes exhibited reduced inflammatory margins compared to Pt–Ir electrodes throughout the subacute period, indicating reduced initial trauma, better overall biocompatibility, and reduced fibrous tissue formation. Coupled with less MRI distortion, CNTY electrodes may be useful alternatives when there is a need to monitor electrode placement by MRI. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12938-015-0113-6) contains supplementary material, which is available to authorized users. BioMed Central 2015-12-21 /pmc/articles/PMC4687330/ /pubmed/26689592 http://dx.doi.org/10.1186/s12938-015-0113-6 Text en © Guo et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Guo, Yi Duan, Wanru Ma, Chao Jiang, Changqing Xie, Yikuan Hao, Hongwei Wang, Renzhi Li, Luming Biocompatibility and magnetic resonance imaging characteristics of carbon nanotube yarn neural electrodes in a rat model |
title | Biocompatibility and magnetic resonance imaging characteristics of carbon nanotube yarn neural electrodes in a rat model |
title_full | Biocompatibility and magnetic resonance imaging characteristics of carbon nanotube yarn neural electrodes in a rat model |
title_fullStr | Biocompatibility and magnetic resonance imaging characteristics of carbon nanotube yarn neural electrodes in a rat model |
title_full_unstemmed | Biocompatibility and magnetic resonance imaging characteristics of carbon nanotube yarn neural electrodes in a rat model |
title_short | Biocompatibility and magnetic resonance imaging characteristics of carbon nanotube yarn neural electrodes in a rat model |
title_sort | biocompatibility and magnetic resonance imaging characteristics of carbon nanotube yarn neural electrodes in a rat model |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687330/ https://www.ncbi.nlm.nih.gov/pubmed/26689592 http://dx.doi.org/10.1186/s12938-015-0113-6 |
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