Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures

BACKGROUND: Fragile X syndrome (FXS) is a neurodevelopmental disorder whose biochemical manifestations involve dysregulation of mGluR5-dependent pathways, which are widely modeled using cultured neurons. In vitro phenotypes in cultured neurons using standard morphological, functional, and chemical a...

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Detalles Bibliográficos
Autores principales: Prilutsky, Daria, Kho, Alvin T., Palmer, Nathan P., Bhakar, Asha L., Smedemark-Margulies, Niklas, Kong, Sek Won, Margulies, David M., Bear, Mark F., Kohane, Isaac S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687343/
https://www.ncbi.nlm.nih.gov/pubmed/26697163
http://dx.doi.org/10.1186/s13229-015-0061-9

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