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First case of Propionibacterium acnes urinary tract infection in a dog

BACKGROUND: Propionibacterium acnes has been rarely isolated as a commensal from dogs, but there is little evidence of pathogenicity. Urinary tract infections are common in dogs and are typically caused by various commensal bacteria. Here we present the first case report of a urinary tract infection...

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Autores principales: Harada, Kazuki, Shimizu, Takae, Tsuka, Takeshi, Imagawa, Tomohiro, Takeuchi, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687383/
https://www.ncbi.nlm.nih.gov/pubmed/26690238
http://dx.doi.org/10.1186/s12917-015-0620-5
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author Harada, Kazuki
Shimizu, Takae
Tsuka, Takeshi
Imagawa, Tomohiro
Takeuchi, Takashi
author_facet Harada, Kazuki
Shimizu, Takae
Tsuka, Takeshi
Imagawa, Tomohiro
Takeuchi, Takashi
author_sort Harada, Kazuki
collection PubMed
description BACKGROUND: Propionibacterium acnes has been rarely isolated as a commensal from dogs, but there is little evidence of pathogenicity. Urinary tract infections are common in dogs and are typically caused by various commensal bacteria. Here we present the first case report of a urinary tract infection caused by P. acnes. CASE PRESENTATION: A 6-year-old female Japanese Shiba Inu was hospitalized for polyuria, polydipsia, and severe hematuria. At admission, blood tests revealed leukocytosis, slight anemia, decreased albumin, and slightly elevated blood urea nitrogen. Computerized tomography showed gas accumulation on the inner side of the bladder wall. Urinalysis revealed proteinuria and bilirubinuria without glycosuria. The urine sediment contained large numbers of erythrocytes and leukocytes. Additionally, rod-shaped bacteria were detected by Diff-Quik staining. Enrofloxacin and metronidazole were administered empirically; however, the renal function declined sharply and the patient died 2 days later. Bacteriological examination revealed that the causative agent was Propionibacterium acnes, which was identified as sequence type 53 via multilocus sequence typing. This isolate showed high susceptibility to ampicillin, amoxicillin/clavulanic acid, cefoxitin, imipenem, clindamycin, tetracycline, chloramphenicol, and enrofloxacin, but was resistant to metronidazole. CONCLUSION: To the best of our knowledge, this is the first case report of a dog with urinary tract infection caused by P. acnes.
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spelling pubmed-46873832015-12-23 First case of Propionibacterium acnes urinary tract infection in a dog Harada, Kazuki Shimizu, Takae Tsuka, Takeshi Imagawa, Tomohiro Takeuchi, Takashi BMC Vet Res Case Report BACKGROUND: Propionibacterium acnes has been rarely isolated as a commensal from dogs, but there is little evidence of pathogenicity. Urinary tract infections are common in dogs and are typically caused by various commensal bacteria. Here we present the first case report of a urinary tract infection caused by P. acnes. CASE PRESENTATION: A 6-year-old female Japanese Shiba Inu was hospitalized for polyuria, polydipsia, and severe hematuria. At admission, blood tests revealed leukocytosis, slight anemia, decreased albumin, and slightly elevated blood urea nitrogen. Computerized tomography showed gas accumulation on the inner side of the bladder wall. Urinalysis revealed proteinuria and bilirubinuria without glycosuria. The urine sediment contained large numbers of erythrocytes and leukocytes. Additionally, rod-shaped bacteria were detected by Diff-Quik staining. Enrofloxacin and metronidazole were administered empirically; however, the renal function declined sharply and the patient died 2 days later. Bacteriological examination revealed that the causative agent was Propionibacterium acnes, which was identified as sequence type 53 via multilocus sequence typing. This isolate showed high susceptibility to ampicillin, amoxicillin/clavulanic acid, cefoxitin, imipenem, clindamycin, tetracycline, chloramphenicol, and enrofloxacin, but was resistant to metronidazole. CONCLUSION: To the best of our knowledge, this is the first case report of a dog with urinary tract infection caused by P. acnes. BioMed Central 2015-12-21 /pmc/articles/PMC4687383/ /pubmed/26690238 http://dx.doi.org/10.1186/s12917-015-0620-5 Text en © Harada et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Harada, Kazuki
Shimizu, Takae
Tsuka, Takeshi
Imagawa, Tomohiro
Takeuchi, Takashi
First case of Propionibacterium acnes urinary tract infection in a dog
title First case of Propionibacterium acnes urinary tract infection in a dog
title_full First case of Propionibacterium acnes urinary tract infection in a dog
title_fullStr First case of Propionibacterium acnes urinary tract infection in a dog
title_full_unstemmed First case of Propionibacterium acnes urinary tract infection in a dog
title_short First case of Propionibacterium acnes urinary tract infection in a dog
title_sort first case of propionibacterium acnes urinary tract infection in a dog
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687383/
https://www.ncbi.nlm.nih.gov/pubmed/26690238
http://dx.doi.org/10.1186/s12917-015-0620-5
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