JAK/STAT signaling in Drosophila muscles controls the cellular immune response against parasitoid infection

The role of JAK/STAT signaling in the cellular immune response of Drosophila is not well understood. Here, we show that parasitoid wasp infection activates JAK/STAT signaling in somatic muscles of the Drosophila larva, triggered by secretion of the cytokines Upd2 and Upd3 from circulating hemocytes....

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Hairu, Kronhamn, Jesper, Ekström, Jens‐Ola, Korkut, Gül Gizem, Hultmark, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687419/
https://www.ncbi.nlm.nih.gov/pubmed/26412855
http://dx.doi.org/10.15252/embr.201540277
_version_ 1782406631031570432
author Yang, Hairu
Kronhamn, Jesper
Ekström, Jens‐Ola
Korkut, Gül Gizem
Hultmark, Dan
author_facet Yang, Hairu
Kronhamn, Jesper
Ekström, Jens‐Ola
Korkut, Gül Gizem
Hultmark, Dan
author_sort Yang, Hairu
collection PubMed
description The role of JAK/STAT signaling in the cellular immune response of Drosophila is not well understood. Here, we show that parasitoid wasp infection activates JAK/STAT signaling in somatic muscles of the Drosophila larva, triggered by secretion of the cytokines Upd2 and Upd3 from circulating hemocytes. Deletion of upd2 or upd3, but not the related os (upd1) gene, reduced the cellular immune response, and suppression of the JAK/STAT pathway in muscle cells reduced the encapsulation of wasp eggs and the number of circulating lamellocyte effector cells. These results suggest that JAK/STAT signaling in muscles participates in a systemic immune defense against wasp infection.
format Online
Article
Text
id pubmed-4687419
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-46874192015-12-30 JAK/STAT signaling in Drosophila muscles controls the cellular immune response against parasitoid infection Yang, Hairu Kronhamn, Jesper Ekström, Jens‐Ola Korkut, Gül Gizem Hultmark, Dan EMBO Rep Articles The role of JAK/STAT signaling in the cellular immune response of Drosophila is not well understood. Here, we show that parasitoid wasp infection activates JAK/STAT signaling in somatic muscles of the Drosophila larva, triggered by secretion of the cytokines Upd2 and Upd3 from circulating hemocytes. Deletion of upd2 or upd3, but not the related os (upd1) gene, reduced the cellular immune response, and suppression of the JAK/STAT pathway in muscle cells reduced the encapsulation of wasp eggs and the number of circulating lamellocyte effector cells. These results suggest that JAK/STAT signaling in muscles participates in a systemic immune defense against wasp infection. John Wiley and Sons Inc. 2015-09-27 2015-12 /pmc/articles/PMC4687419/ /pubmed/26412855 http://dx.doi.org/10.15252/embr.201540277 Text en © 2015 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the Creative Commons Attribution 4.0 (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Yang, Hairu
Kronhamn, Jesper
Ekström, Jens‐Ola
Korkut, Gül Gizem
Hultmark, Dan
JAK/STAT signaling in Drosophila muscles controls the cellular immune response against parasitoid infection
title JAK/STAT signaling in Drosophila muscles controls the cellular immune response against parasitoid infection
title_full JAK/STAT signaling in Drosophila muscles controls the cellular immune response against parasitoid infection
title_fullStr JAK/STAT signaling in Drosophila muscles controls the cellular immune response against parasitoid infection
title_full_unstemmed JAK/STAT signaling in Drosophila muscles controls the cellular immune response against parasitoid infection
title_short JAK/STAT signaling in Drosophila muscles controls the cellular immune response against parasitoid infection
title_sort jak/stat signaling in drosophila muscles controls the cellular immune response against parasitoid infection
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687419/
https://www.ncbi.nlm.nih.gov/pubmed/26412855
http://dx.doi.org/10.15252/embr.201540277
work_keys_str_mv AT yanghairu jakstatsignalingindrosophilamusclescontrolsthecellularimmuneresponseagainstparasitoidinfection
AT kronhamnjesper jakstatsignalingindrosophilamusclescontrolsthecellularimmuneresponseagainstparasitoidinfection
AT ekstromjensola jakstatsignalingindrosophilamusclescontrolsthecellularimmuneresponseagainstparasitoidinfection
AT korkutgulgizem jakstatsignalingindrosophilamusclescontrolsthecellularimmuneresponseagainstparasitoidinfection
AT hultmarkdan jakstatsignalingindrosophilamusclescontrolsthecellularimmuneresponseagainstparasitoidinfection

Ejemplares similares