Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer

Aberrant regulation of the Wnt/β-catenin signaling pathway is one of the major causes of colorectal cancer (CRC). Loss-of-function mutations in APC are commonly found in CRC, leading to inappropriate activation of canonical Wnt signaling. Conversely, gain-of-function mutations in KRAS and BRAF genes...

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Detalles Bibliográficos
Autores principales: Lemieux, E, Cagnol, S, Beaudry, K, Carrier, J, Rivard, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687460/
https://www.ncbi.nlm.nih.gov/pubmed/25500543
http://dx.doi.org/10.1038/onc.2014.416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687460/
https://www.ncbi.nlm.nih.gov/pubmed/25500543
http://dx.doi.org/10.1038/onc.2014.416

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