The external domains of the HIV-1 envelope are a mutational cold spot

In RNA viruses, mutations occur fast and have large fitness effects. While this affords remarkable adaptability, it can also endanger viral survival due to the accumulation of deleterious mutations. How RNA viruses reconcile these two opposed facets of mutation is still unknown. Here we show that, i...

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Detalles Bibliográficos
Autores principales: Geller, Ron, Domingo-Calap, Pilar, Cuevas, José M., Rossolillo, Paola, Negroni, Matteo, Sanjuán, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687473/
https://www.ncbi.nlm.nih.gov/pubmed/26450412
http://dx.doi.org/10.1038/ncomms9571

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