Cargando…

Packed Bed Bioreactor for the Isolation and Expansion of Placental-Derived Mesenchymal Stromal Cells

Large numbers of Mesenchymal stem/stromal cells (MSCs) are required for clinical relevant doses to treat a number of diseases. To economically manufacture these MSCs, an automated bioreactor system will be required. Herein we describe the development of a scalable closed-system, packed bed bioreacto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Osiecki, Michael J., Michl, Thomas D., Kul Babur, Betul, Kabiri, Mahboubeh, Atkinson, Kerry, Lott, William B., Griesser, Hans J., Doran, Michael R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687640/ https://www.ncbi.nlm.nih.gov/pubmed/26660475 http://dx.doi.org/10.1371/journal.pone.0144941

Ejemplares similares

Modelling mesenchymal stromal cell growth in a packed bed bioreactor with a gas permeable wall
por: Osiecki, Michael J., et al.
Publicado: (2018)

The Rapid Manufacture of Uniform Composite Multicellular-Biomaterial Micropellets, Their Assembly into Macroscopic Organized Tissues, and Potential Applications in Cartilage Tissue Engineering
por: Kul Babur, Betul, et al.
Publicado: (2015)

Assessment of packed bed bioreactor systems in the production of viral vaccines
por: Rajendran, Ramya, et al.
Publicado: (2014)

Spheroid Coculture of Hematopoietic Stem/Progenitor Cells and Monolayer Expanded Mesenchymal Stem/Stromal Cells in Polydimethylsiloxane Microwells Modestly Improves In Vitro Hematopoietic Stem/Progenitor Cell Expansion
por: Futrega, Kathryn, et al.
Publicado: (2017)

High-throughput bone and cartilage micropellet manufacture, followed by assembly of micropellets into biphasic osteochondral tissue
por: Babur, Betul Kul, et al.
Publicado: (2015)

Biodegradation of Iprodione and Chlorpyrifos Using an Immobilized Bacterial Consortium in a Packed-Bed Bioreactor
por: Levío-Raimán, Marcela, et al.
Publicado: (2023)

Operational parameters and their influence on particle-side mass transfer resistance in a packed bed bioreactor
por: Hussain, Amir, et al.
Publicado: (2015)

Biological wheat straw valorization: Multicriteria optimization of Polyporus brumalis pretreatment in packed bed bioreactor
por: Zhou, Simeng, et al.
Publicado: (2017)

Lentiviral Vector Production from a Stable Packaging Cell Line Using a Packed Bed Bioreactor
por: Powers, Alicia D., et al.
Publicado: (2020)

The Interplay between Chondrocyte Redifferentiation Pellet Size and Oxygen Concentration
por: Babur, Betul Kul, et al.
Publicado: (2013)

Performance evaluation of conventional membrane bioreactor and moving bed membrane bioreactor for synthetic textile wastewater treatment
por: Sari Erkan, Hanife, et al.
Publicado: (2020)

Influence of operational parameters on the fluid-side mass transfer resistance observed in a packed bed bioreactor
por: Hussain, Amir, et al.
Publicado: (2015)

A Critical Remark on the Applications of Gas-Phase Biofilter (Packed-Bed Bioreactor) Models in Aqueous Systems
por: Shareefdeen, Zarook, et al.
Publicado: (2022)

Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue
por: Pelekanos, Rebecca A., et al.
Publicado: (2016)

Biodegradation of Indanthrene Blue RS dye in immobilized continuous upflow packed bed bioreactor using corncob biochar
por: Mohanty, Swati Sambita, et al.
Publicado: (2021)

4-chlorophenol removal by air lift packed bed bioreactor and its modeling by kinetics and numerical model (artificial neural network)
por: Azizi, Elahe, et al.
Publicado: (2021)

High Performance of Biohydrogen Production in Packed-Filter Bioreactor via Optimizing Packed-Filter Position
por: Chu, Chen-Yeon, et al.
Publicado: (2021)

Improved expansion of equine cord blood derived mesenchymal stromal cells by using microcarriers in stirred suspension bioreactors
por: Roberts, Erin L., et al.
Publicado: (2019)

Bioreactor Scalability: Laboratory-Scale Bioreactor Design Influences Performance, Ecology, and Community Physiology in Expanded Granular Sludge Bed Bioreactors
por: Connelly, Stephanie, et al.
Publicado: (2017)

Production of a chimeric porcine reproductive and respiratory syndrome virus (PRRSV)-2 vaccine using a lab-scale packed-bed bioreactor CelCradle
por: Choi, Hwi-Yeon, et al.
Publicado: (2023)

Large Scale Expansion of Human Umbilical Cord Cells in a Rotating Bed System Bioreactor for Cardiovascular Tissue Engineering Applications
por: Reichardt, Anne, et al.
Publicado: (2013)

Correction: Production of a chimeric porcine reproductive and respiratory syndrome virus (PRRSV)-2 vaccine using a lab-scale packed-bed bioreactor CelCradle
por: Choi, Hwi-Yeon, et al.
Publicado: (2023)

An experimental study on coflow diffusion combustion in a pellet-packed bed with different bed lengths
por: Shi, Junrui, et al.
Publicado: (2018)

Association between Mastitis Occurrence in Dairy Cows and Bedding Characteristics of Compost-Bedded Pack Barns
por: Freu, Gustavo, et al.
Publicado: (2023)

Experimental data on water vapour adsorption on silica gel in fully packed and Z-annulus packed beds
por: Yeboah, Siegfried K., et al.
Publicado: (2021)

Optimization of lentiviral vector production for scale-up in fixed-bed bioreactor
por: Valkama, A J, et al.
Publicado: (2018)

Media and microcarrier surface must be optimized when transitioning mesenchymal stem/stromal cell expansion to stirred tank bioreactors
por: Schnitzler, Aletta, et al.
Publicado: (2015)

Computer controlled expansion of equine cord blood mesenchymal stromal cells on microcarriers in 3 L vertical-wheel(®) bioreactors
por: Roberts, E. L., et al.
Publicado: (2023)

Simultaneous Coproduction of Hydrogen and Ethanol in Anaerobic Packed-Bed Reactors
por: dos Reis, Cristiane Marques, et al.
Publicado: (2014)

Packed bed reactor for degradation of simulated cyanide-containing wastewater
por: Kumar, Virender, et al.
Publicado: (2014)

Biotransformation of ferulic acid to vanillin in the packed bed-stirred fermentors
por: Yan, Lei, et al.
Publicado: (2016)

Performance of an Indirect Packed Bed Reactor for Chemical Energy Storage
por: Delise, Tiziano, et al.
Publicado: (2021)

Treatment of Pharma Effluent using Anaerobic Packed Bed Reactor
por: Vijayan, D. S., et al.
Publicado: (2022)

An original Arduino-controlled anaerobic bioreactor packed with biochar as a porous filter media
por: Küçükağa, Yusuf, et al.
Publicado: (2022)

Optimizing T Cell Expansion in a Hollow-Fiber Bioreactor
por: Nankervis, Brian, et al.
Publicado: (2018)

Lymphocyte expansion in bioreactors: upgrading adoptive cell therapy
por: Garcia-Aponte, Oscar Fabian, et al.
Publicado: (2021)

CFD simulation of gas pressure drop in porous packing for rotating packed beds (RPB) CO(2) absorbers
por: Wojtasik-Malinowska, Justyna, et al.
Publicado: (2022)

Proteomic Identification and Time-Course Monitoring of Secreted Proteins During Expansion of Human Mesenchymal Stem/Stromal in Stirred-Tank Bioreactor
por: Mizukami, Amanda, et al.
Publicado: (2019)

Fructose Production by Inulinase Covalently Immobilized on Sepabeads in Batch and Fluidized Bed Bioreactor
por: Ricca, Emanuele, et al.
Publicado: (2010)

Impacts of Compost Bedded Pack Barns on the Welfare and Comfort of Dairy Cows
por: Fernández, Anna, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2mfpagrd08oal21m2q6i0rpr3e